Tau deposition is associated with functional isolation of the hippocampus in aging

Deposition of tau protein aggregates occurs during aging and Alzheimer disease. Here, the authors show that tau burden in the anterior-temporal memory network is associated with disrupted fMRI connectivity and functional isolation of the hippocampus from other memory network components.

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Autores principales:	Theresa M. Harrison, Anne Maass, Jenna N. Adams, Richard Du, Suzanne L. Baker, William J. Jagust
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/943d6b83e00c49b4bc60134224b62d84
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spelling	oai:doaj.org-article:943d6b83e00c49b4bc60134224b62d842021-12-02T16:58:26ZTau deposition is associated with functional isolation of the hippocampus in aging10.1038/s41467-019-12921-z2041-1723https://doaj.org/article/943d6b83e00c49b4bc60134224b62d842019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12921-zhttps://doaj.org/toc/2041-1723Deposition of tau protein aggregates occurs during aging and Alzheimer disease. Here, the authors show that tau burden in the anterior-temporal memory network is associated with disrupted fMRI connectivity and functional isolation of the hippocampus from other memory network components.Theresa M. HarrisonAnne MaassJenna N. AdamsRichard DuSuzanne L. BakerWilliam J. JagustNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Theresa M. Harrison Anne Maass Jenna N. Adams Richard Du Suzanne L. Baker William J. Jagust Tau deposition is associated with functional isolation of the hippocampus in aging
description	Deposition of tau protein aggregates occurs during aging and Alzheimer disease. Here, the authors show that tau burden in the anterior-temporal memory network is associated with disrupted fMRI connectivity and functional isolation of the hippocampus from other memory network components.
format	article
author	Theresa M. Harrison Anne Maass Jenna N. Adams Richard Du Suzanne L. Baker William J. Jagust
author_facet	Theresa M. Harrison Anne Maass Jenna N. Adams Richard Du Suzanne L. Baker William J. Jagust
author_sort	Theresa M. Harrison
title	Tau deposition is associated with functional isolation of the hippocampus in aging
title_short	Tau deposition is associated with functional isolation of the hippocampus in aging
title_full	Tau deposition is associated with functional isolation of the hippocampus in aging
title_fullStr	Tau deposition is associated with functional isolation of the hippocampus in aging
title_full_unstemmed	Tau deposition is associated with functional isolation of the hippocampus in aging
title_sort	tau deposition is associated with functional isolation of the hippocampus in aging
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/943d6b83e00c49b4bc60134224b62d84
work_keys_str_mv	AT theresamharrison taudepositionisassociatedwithfunctionalisolationofthehippocampusinaging AT annemaass taudepositionisassociatedwithfunctionalisolationofthehippocampusinaging AT jennanadams taudepositionisassociatedwithfunctionalisolationofthehippocampusinaging AT richarddu taudepositionisassociatedwithfunctionalisolationofthehippocampusinaging AT suzannelbaker taudepositionisassociatedwithfunctionalisolationofthehippocampusinaging AT williamjjagust taudepositionisassociatedwithfunctionalisolationofthehippocampusinaging
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Tau deposition is associated with functional isolation of the hippocampus in aging

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