Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP–PKA signaling

The molecular mechanism by which clock neurons transmit timing information to non-clock neurons is poorly understood. Here, the authors show that circadian clocks drive rhythmic expression of hundreds of genes in mushroom body neurons and drive calcium rhythms via NF1-cAMP/PKAC1 signalling in Drosop...

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Autores principales:	Pedro Machado Almeida, Blanca Lago Solis, Luca Stickley, Alexis Feidler, Emi Nagoshi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/94595f06ca7140c8bcb73b922389b343
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spelling	oai:doaj.org-article:94595f06ca7140c8bcb73b922389b3432021-12-02T18:51:23ZNeurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP–PKA signaling10.1038/s41467-021-26031-22041-1723https://doaj.org/article/94595f06ca7140c8bcb73b922389b3432021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26031-2https://doaj.org/toc/2041-1723The molecular mechanism by which clock neurons transmit timing information to non-clock neurons is poorly understood. Here, the authors show that circadian clocks drive rhythmic expression of hundreds of genes in mushroom body neurons and drive calcium rhythms via NF1-cAMP/PKAC1 signalling in Drosophila.Pedro Machado AlmeidaBlanca Lago SolisLuca StickleyAlexis FeidlerEmi NagoshiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pedro Machado Almeida Blanca Lago Solis Luca Stickley Alexis Feidler Emi Nagoshi Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP–PKA signaling
description	The molecular mechanism by which clock neurons transmit timing information to non-clock neurons is poorly understood. Here, the authors show that circadian clocks drive rhythmic expression of hundreds of genes in mushroom body neurons and drive calcium rhythms via NF1-cAMP/PKAC1 signalling in Drosophila.
format	article
author	Pedro Machado Almeida Blanca Lago Solis Luca Stickley Alexis Feidler Emi Nagoshi
author_facet	Pedro Machado Almeida Blanca Lago Solis Luca Stickley Alexis Feidler Emi Nagoshi
author_sort	Pedro Machado Almeida
title	Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP–PKA signaling
title_short	Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP–PKA signaling
title_full	Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP–PKA signaling
title_fullStr	Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP–PKA signaling
title_full_unstemmed	Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP–PKA signaling
title_sort	neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating camp–pka signaling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/94595f06ca7140c8bcb73b922389b343
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Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP–PKA signaling

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