Crystal structure of Drosophila Piwi

PIWI-clade Argonautes bind PIWI-interacting RNAs (piRNAs) to silence transposons and maintain genome integrity in animal gonads. Here the authors present the crystal structure of a Drosophila Piwi–piRNA complex isolated from cultured fly ovarian somatic cells and find that it contains a non-canonica...

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Autores principales:	Sonomi Yamaguchi, Akira Oe, Kazumichi M. Nishida, Keitaro Yamashita, Asako Kajiya, Seiichi Hirano, Naoki Matsumoto, Naoshi Dohmae, Ryuichiro Ishitani, Kuniaki Saito, Haruhiko Siomi, Hiroshi Nishimasu, Mikiko C. Siomi, Osamu Nureki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9479ad5dbf9b4bffacfb69fcd7468085
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spelling	oai:doaj.org-article:9479ad5dbf9b4bffacfb69fcd74680852021-12-02T15:37:11ZCrystal structure of Drosophila Piwi10.1038/s41467-020-14687-12041-1723https://doaj.org/article/9479ad5dbf9b4bffacfb69fcd74680852020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14687-1https://doaj.org/toc/2041-1723PIWI-clade Argonautes bind PIWI-interacting RNAs (piRNAs) to silence transposons and maintain genome integrity in animal gonads. Here the authors present the crystal structure of a Drosophila Piwi–piRNA complex isolated from cultured fly ovarian somatic cells and find that it contains a non-canonical DVDK tetrad, and lacks slicer activity in vitro.Sonomi YamaguchiAkira OeKazumichi M. NishidaKeitaro YamashitaAsako KajiyaSeiichi HiranoNaoki MatsumotoNaoshi DohmaeRyuichiro IshitaniKuniaki SaitoHaruhiko SiomiHiroshi NishimasuMikiko C. SiomiOsamu NurekiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sonomi Yamaguchi Akira Oe Kazumichi M. Nishida Keitaro Yamashita Asako Kajiya Seiichi Hirano Naoki Matsumoto Naoshi Dohmae Ryuichiro Ishitani Kuniaki Saito Haruhiko Siomi Hiroshi Nishimasu Mikiko C. Siomi Osamu Nureki Crystal structure of Drosophila Piwi
description	PIWI-clade Argonautes bind PIWI-interacting RNAs (piRNAs) to silence transposons and maintain genome integrity in animal gonads. Here the authors present the crystal structure of a Drosophila Piwi–piRNA complex isolated from cultured fly ovarian somatic cells and find that it contains a non-canonical DVDK tetrad, and lacks slicer activity in vitro.
format	article
author	Sonomi Yamaguchi Akira Oe Kazumichi M. Nishida Keitaro Yamashita Asako Kajiya Seiichi Hirano Naoki Matsumoto Naoshi Dohmae Ryuichiro Ishitani Kuniaki Saito Haruhiko Siomi Hiroshi Nishimasu Mikiko C. Siomi Osamu Nureki
author_facet	Sonomi Yamaguchi Akira Oe Kazumichi M. Nishida Keitaro Yamashita Asako Kajiya Seiichi Hirano Naoki Matsumoto Naoshi Dohmae Ryuichiro Ishitani Kuniaki Saito Haruhiko Siomi Hiroshi Nishimasu Mikiko C. Siomi Osamu Nureki
author_sort	Sonomi Yamaguchi
title	Crystal structure of Drosophila Piwi
title_short	Crystal structure of Drosophila Piwi
title_full	Crystal structure of Drosophila Piwi
title_fullStr	Crystal structure of Drosophila Piwi
title_full_unstemmed	Crystal structure of Drosophila Piwi
title_sort	crystal structure of drosophila piwi
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9479ad5dbf9b4bffacfb69fcd7468085
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_version_	1718386246265339904

Crystal structure of Drosophila Piwi

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