A gammaherpesvirus cooperates with interferon-alpha/beta-induced IRF2 to halt viral replication, control reactivation, and minimize host lethality.

The gammaherpesviruses, including Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), establish latency in memory B lymphocytes and promote lymphoproliferative disease in immunocompromised individuals. The precise immune mechanisms that prevent gammaherpesvirus reactiva...

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Autores principales: Pratyusha Mandal, Bridgette E Krueger, Darby Oldenburg, Katherine A Andry, R Suzanne Beard, Douglas W White, Erik S Barton
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/94a2f1429edb4acbbeabbb15897745f7
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