Microtubules regulate pancreatic β-cell heterogeneity via spatiotemporal control of insulin secretion hot spots

Microtubules regulate pancreatic β-cell heterogeneity via spatiotemporal control of insulin secretion hot spots

Heterogeneity of glucose-stimulated insulin secretion (GSIS) in pancreatic islets is physiologically important but poorly understood. Here, we utilize mouse islets to determine how microtubules (MTs) affect secretion toward the vascular extracellular matrix at single cell and subcellular levels. Our...

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Détails bibliographiques
Auteurs principaux: Kathryn P Trogden, Justin Lee, Kai M Bracey, Kung-Hsien Ho, Hudson McKinney, Xiaodong Zhu, Goker Arpag, Thomas G Folland, Anna B Osipovich, Mark A Magnuson, Marija Zanic, Guoqiang Gu, William R Holmes, Irina Kaverina
Format: article
Langue:EN
Publié: eLife Sciences Publications Ltd 2021
Sujets:
microtubule stability
diabetes
biphasic secretion
stimulus-secretion coupling
computational cluster analysis
microtubule dynamics
Medicine
R
Science
Q
Biology (General)
QH301-705.5
Accès en ligne:https://doaj.org/article/9506901faa9e40da9a5c9f740c2f02ad
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https://doaj.org/article/9506901faa9e40da9a5c9f740c2f02ad

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