Microtubules regulate pancreatic β-cell heterogeneity via spatiotemporal control of insulin secretion hot spots

Heterogeneity of glucose-stimulated insulin secretion (GSIS) in pancreatic islets is physiologically important but poorly understood. Here, we utilize mouse islets to determine how microtubules (MTs) affect secretion toward the vascular extracellular matrix at single cell and subcellular levels. Our...

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Autores principales:	Kathryn P Trogden, Justin Lee, Kai M Bracey, Kung-Hsien Ho, Hudson McKinney, Xiaodong Zhu, Goker Arpag, Thomas G Folland, Anna B Osipovich, Mark A Magnuson, Marija Zanic, Guoqiang Gu, William R Holmes, Irina Kaverina
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	microtubule stability diabetes biphasic secretion stimulus-secretion coupling computational cluster analysis microtubule dynamics Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9506901faa9e40da9a5c9f740c2f02ad
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Microtubules regulate pancreatic β-cell heterogeneity via spatiotemporal control of insulin secretion hot spots

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