Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11.

Vesicular trafficking plays a key role in tuning the activity of Notch signaling. Here, we describe a novel and conserved Rab geranylgeranyltransferase (RabGGT)-α-like subunit that is required for Notch signaling-mediated lateral inhibition and cell fate determination of external sensory organs. Thi...

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Autores principales:	Wu-Lin Charng, Shinya Yamamoto, Manish Jaiswal, Vafa Bayat, Bo Xiong, Ke Zhang, Hector Sandoval, Gabriela David, Stephen Gibbs, Hsiang-Chih Lu, Kuchuan Chen, Nikos Giagtzoglou, Hugo J Bellen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/951f0ce1a76b4afb825c7f0b62f3bb46
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spelling	oai:doaj.org-article:951f0ce1a76b4afb825c7f0b62f3bb462021-11-18T05:37:36ZDrosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11.1544-91731545-788510.1371/journal.pbio.1001777https://doaj.org/article/951f0ce1a76b4afb825c7f0b62f3bb462014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24492843/pdf/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Vesicular trafficking plays a key role in tuning the activity of Notch signaling. Here, we describe a novel and conserved Rab geranylgeranyltransferase (RabGGT)-α-like subunit that is required for Notch signaling-mediated lateral inhibition and cell fate determination of external sensory organs. This protein is encoded by tempura, and its loss affects the secretion of Scabrous and Delta, two proteins required for proper Notch signaling. We show that Tempura forms a heretofore uncharacterized RabGGT complex that geranylgeranylates Rab1 and Rab11. This geranylgeranylation is required for their proper subcellular localization. A partial dysfunction of Rab1 affects Scabrous and Delta in the secretory pathway. In addition, a partial loss Rab11 affects trafficking of Delta. In summary, Tempura functions as a new geranylgeranyltransferase that regulates the subcellular localization of Rab1 and Rab11, which in turn regulate trafficking of Scabrous and Delta, thereby affecting Notch signaling.Wu-Lin CharngShinya YamamotoManish JaiswalVafa BayatBo XiongKe ZhangHector SandovalGabriela DavidStephen GibbsHsiang-Chih LuKuchuan ChenNikos GiagtzoglouHugo J BellenPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 12, Iss 1, p e1001777 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Wu-Lin Charng Shinya Yamamoto Manish Jaiswal Vafa Bayat Bo Xiong Ke Zhang Hector Sandoval Gabriela David Stephen Gibbs Hsiang-Chih Lu Kuchuan Chen Nikos Giagtzoglou Hugo J Bellen Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11.
description	Vesicular trafficking plays a key role in tuning the activity of Notch signaling. Here, we describe a novel and conserved Rab geranylgeranyltransferase (RabGGT)-α-like subunit that is required for Notch signaling-mediated lateral inhibition and cell fate determination of external sensory organs. This protein is encoded by tempura, and its loss affects the secretion of Scabrous and Delta, two proteins required for proper Notch signaling. We show that Tempura forms a heretofore uncharacterized RabGGT complex that geranylgeranylates Rab1 and Rab11. This geranylgeranylation is required for their proper subcellular localization. A partial dysfunction of Rab1 affects Scabrous and Delta in the secretory pathway. In addition, a partial loss Rab11 affects trafficking of Delta. In summary, Tempura functions as a new geranylgeranyltransferase that regulates the subcellular localization of Rab1 and Rab11, which in turn regulate trafficking of Scabrous and Delta, thereby affecting Notch signaling.
format	article
author	Wu-Lin Charng Shinya Yamamoto Manish Jaiswal Vafa Bayat Bo Xiong Ke Zhang Hector Sandoval Gabriela David Stephen Gibbs Hsiang-Chih Lu Kuchuan Chen Nikos Giagtzoglou Hugo J Bellen
author_facet	Wu-Lin Charng Shinya Yamamoto Manish Jaiswal Vafa Bayat Bo Xiong Ke Zhang Hector Sandoval Gabriela David Stephen Gibbs Hsiang-Chih Lu Kuchuan Chen Nikos Giagtzoglou Hugo J Bellen
author_sort	Wu-Lin Charng
title	Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11.
title_short	Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11.
title_full	Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11.
title_fullStr	Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11.
title_full_unstemmed	Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11.
title_sort	drosophila tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via rab1 and rab11.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/951f0ce1a76b4afb825c7f0b62f3bb46
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Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11.

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