Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome

Complex diseases often share genetic determinants and symptoms, but the mechanistic basis of disease interactions remains elusive. Here, the authors propose a network topological measure to identify proteins linking complex diseases in the interactome, and identify mediators between COPD and asthma.

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Bibliographic Details
Main Authors: Enrico Maiorino, Seung Han Baek, Feng Guo, Xiaobo Zhou, Parul H. Kothari, Edwin K. Silverman, Albert-László Barabási, Scott T. Weiss, Benjamin A. Raby, Amitabh Sharma
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/95353d29e28049fbaf770305d65dd8a5
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