Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome

Complex diseases often share genetic determinants and symptoms, but the mechanistic basis of disease interactions remains elusive. Here, the authors propose a network topological measure to identify proteins linking complex diseases in the interactome, and identify mediators between COPD and asthma.

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Autores principales:	Enrico Maiorino, Seung Han Baek, Feng Guo, Xiaobo Zhou, Parul H. Kothari, Edwin K. Silverman, Albert-László Barabási, Scott T. Weiss, Benjamin A. Raby, Amitabh Sharma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/95353d29e28049fbaf770305d65dd8a5
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spelling	oai:doaj.org-article:95353d29e28049fbaf770305d65dd8a52021-12-02T17:31:40ZDiscovering the genes mediating the interactions between chronic respiratory diseases in the human interactome10.1038/s41467-020-14600-w2041-1723https://doaj.org/article/95353d29e28049fbaf770305d65dd8a52020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14600-whttps://doaj.org/toc/2041-1723Complex diseases often share genetic determinants and symptoms, but the mechanistic basis of disease interactions remains elusive. Here, the authors propose a network topological measure to identify proteins linking complex diseases in the interactome, and identify mediators between COPD and asthma.Enrico MaiorinoSeung Han BaekFeng GuoXiaobo ZhouParul H. KothariEdwin K. SilvermanAlbert-László BarabásiScott T. WeissBenjamin A. RabyAmitabh SharmaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Enrico Maiorino Seung Han Baek Feng Guo Xiaobo Zhou Parul H. Kothari Edwin K. Silverman Albert-László Barabási Scott T. Weiss Benjamin A. Raby Amitabh Sharma Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome
description	Complex diseases often share genetic determinants and symptoms, but the mechanistic basis of disease interactions remains elusive. Here, the authors propose a network topological measure to identify proteins linking complex diseases in the interactome, and identify mediators between COPD and asthma.
format	article
author	Enrico Maiorino Seung Han Baek Feng Guo Xiaobo Zhou Parul H. Kothari Edwin K. Silverman Albert-László Barabási Scott T. Weiss Benjamin A. Raby Amitabh Sharma
author_facet	Enrico Maiorino Seung Han Baek Feng Guo Xiaobo Zhou Parul H. Kothari Edwin K. Silverman Albert-László Barabási Scott T. Weiss Benjamin A. Raby Amitabh Sharma
author_sort	Enrico Maiorino
title	Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome
title_short	Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome
title_full	Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome
title_fullStr	Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome
title_full_unstemmed	Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome
title_sort	discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/95353d29e28049fbaf770305d65dd8a5
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Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome

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