Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome

Complex diseases often share genetic determinants and symptoms, but the mechanistic basis of disease interactions remains elusive. Here, the authors propose a network topological measure to identify proteins linking complex diseases in the interactome, and identify mediators between COPD and asthma.

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Autores principales: Enrico Maiorino, Seung Han Baek, Feng Guo, Xiaobo Zhou, Parul H. Kothari, Edwin K. Silverman, Albert-László Barabási, Scott T. Weiss, Benjamin A. Raby, Amitabh Sharma
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/95353d29e28049fbaf770305d65dd8a5
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