Collective synthesis of acetylenic pharmaceuticals via enantioselective Nickel/Lewis acid-catalyzed propargylic alkylation
Chiral acetylenic derivatives are found in many bioactive compounds and are versatile building blocks in organic synthesis. Here, the authors report a mild enantioselective nickel/Lewis acid-catalyzed asymmetric propargylic substitution reaction which is applied to the collective synthesis of seven...
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| Autores principales: | , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/95457fe0465d451bbe506907cf00b536 |
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