Collective synthesis of acetylenic pharmaceuticals via enantioselective Nickel/Lewis acid-catalyzed propargylic alkylation

Chiral acetylenic derivatives are found in many bioactive compounds and are versatile building blocks in organic synthesis. Here, the authors report a mild enantioselective nickel/Lewis acid-catalyzed asymmetric propargylic substitution reaction which is applied to the collective synthesis of seven...

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Autores principales:	Xihao Chang, Jiayin Zhang, Lingzi Peng, Chang Guo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/95457fe0465d451bbe506907cf00b536
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spelling	oai:doaj.org-article:95457fe0465d451bbe506907cf00b5362021-12-02T15:22:40ZCollective synthesis of acetylenic pharmaceuticals via enantioselective Nickel/Lewis acid-catalyzed propargylic alkylation10.1038/s41467-020-20644-92041-1723https://doaj.org/article/95457fe0465d451bbe506907cf00b5362021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20644-9https://doaj.org/toc/2041-1723Chiral acetylenic derivatives are found in many bioactive compounds and are versatile building blocks in organic synthesis. Here, the authors report a mild enantioselective nickel/Lewis acid-catalyzed asymmetric propargylic substitution reaction which is applied to the collective synthesis of seven biologically active compounds.Xihao ChangJiayin ZhangLingzi PengChang GuoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xihao Chang Jiayin Zhang Lingzi Peng Chang Guo Collective synthesis of acetylenic pharmaceuticals via enantioselective Nickel/Lewis acid-catalyzed propargylic alkylation
description	Chiral acetylenic derivatives are found in many bioactive compounds and are versatile building blocks in organic synthesis. Here, the authors report a mild enantioselective nickel/Lewis acid-catalyzed asymmetric propargylic substitution reaction which is applied to the collective synthesis of seven biologically active compounds.
format	article
author	Xihao Chang Jiayin Zhang Lingzi Peng Chang Guo
author_facet	Xihao Chang Jiayin Zhang Lingzi Peng Chang Guo
author_sort	Xihao Chang
title	Collective synthesis of acetylenic pharmaceuticals via enantioselective Nickel/Lewis acid-catalyzed propargylic alkylation
title_short	Collective synthesis of acetylenic pharmaceuticals via enantioselective Nickel/Lewis acid-catalyzed propargylic alkylation
title_full	Collective synthesis of acetylenic pharmaceuticals via enantioselective Nickel/Lewis acid-catalyzed propargylic alkylation
title_fullStr	Collective synthesis of acetylenic pharmaceuticals via enantioselective Nickel/Lewis acid-catalyzed propargylic alkylation
title_full_unstemmed	Collective synthesis of acetylenic pharmaceuticals via enantioselective Nickel/Lewis acid-catalyzed propargylic alkylation
title_sort	collective synthesis of acetylenic pharmaceuticals via enantioselective nickel/lewis acid-catalyzed propargylic alkylation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/95457fe0465d451bbe506907cf00b536
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Collective synthesis of acetylenic pharmaceuticals via enantioselective Nickel/Lewis acid-catalyzed propargylic alkylation

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