Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction

The enzyme serine hydroxymethyltransferase (SHMT) has been implicated in several diseases, however is hard to investigate. Here, the authors used a design strategy based on the retro-aldol-type reaction catalyzed by SHMT to develop SHMT-responsive fluorescence and 19F NMR molecular probes.

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Autores principales:	Hiroshi Nonaka, Yuki Nakanishi, Satoshi Kuno, Tomoki Ota, Kentaro Mochidome, Yutaro Saito, Fuminori Sugihara, Yoichi Takakusagi, Ichio Aoki, Satoru Nagatoishi, Kouhei Tsumoto, Shinsuke Sando
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/95960802fdea4dd5b7793046d2f3732b
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spelling	oai:doaj.org-article:95960802fdea4dd5b7793046d2f3732b2021-12-02T16:50:57ZDesign strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction10.1038/s41467-019-08833-72041-1723https://doaj.org/article/95960802fdea4dd5b7793046d2f3732b2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08833-7https://doaj.org/toc/2041-1723The enzyme serine hydroxymethyltransferase (SHMT) has been implicated in several diseases, however is hard to investigate. Here, the authors used a design strategy based on the retro-aldol-type reaction catalyzed by SHMT to develop SHMT-responsive fluorescence and 19F NMR molecular probes.Hiroshi NonakaYuki NakanishiSatoshi KunoTomoki OtaKentaro MochidomeYutaro SaitoFuminori SugiharaYoichi TakakusagiIchio AokiSatoru NagatoishiKouhei TsumotoShinsuke SandoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hiroshi Nonaka Yuki Nakanishi Satoshi Kuno Tomoki Ota Kentaro Mochidome Yutaro Saito Fuminori Sugihara Yoichi Takakusagi Ichio Aoki Satoru Nagatoishi Kouhei Tsumoto Shinsuke Sando Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction
description	The enzyme serine hydroxymethyltransferase (SHMT) has been implicated in several diseases, however is hard to investigate. Here, the authors used a design strategy based on the retro-aldol-type reaction catalyzed by SHMT to develop SHMT-responsive fluorescence and 19F NMR molecular probes.
format	article
author	Hiroshi Nonaka Yuki Nakanishi Satoshi Kuno Tomoki Ota Kentaro Mochidome Yutaro Saito Fuminori Sugihara Yoichi Takakusagi Ichio Aoki Satoru Nagatoishi Kouhei Tsumoto Shinsuke Sando
author_facet	Hiroshi Nonaka Yuki Nakanishi Satoshi Kuno Tomoki Ota Kentaro Mochidome Yutaro Saito Fuminori Sugihara Yoichi Takakusagi Ichio Aoki Satoru Nagatoishi Kouhei Tsumoto Shinsuke Sando
author_sort	Hiroshi Nonaka
title	Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction
title_short	Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction
title_full	Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction
title_fullStr	Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction
title_full_unstemmed	Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction
title_sort	design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/95960802fdea4dd5b7793046d2f3732b
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Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction

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