MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells

Naïve pluripotency is characterized by distinctly open chromatin and repressed endogenous retroviruses. Here the authors show that MPP8 and its association with the core HUSH complex is essential for naïve pluripotent cells; also that repression of LINE1 elements by MPP8 does not require chromatin b...

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Autores principales:	Iris Müller, Ann Sophie Moroni, Daria Shlyueva, Sudeep Sahadevan, Erwin M. Schoof, Aliaksandra Radzisheuskaya, Jonas W. Højfeldt, Tülin Tatar, Richard P. Koche, Chang Huang, Kristian Helin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9597bd4ec7404890a76dbc8df6a59f5c
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spelling	oai:doaj.org-article:9597bd4ec7404890a76dbc8df6a59f5c2021-12-02T16:53:07ZMPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells10.1038/s41467-021-23308-42041-1723https://doaj.org/article/9597bd4ec7404890a76dbc8df6a59f5c2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23308-4https://doaj.org/toc/2041-1723Naïve pluripotency is characterized by distinctly open chromatin and repressed endogenous retroviruses. Here the authors show that MPP8 and its association with the core HUSH complex is essential for naïve pluripotent cells; also that repression of LINE1 elements by MPP8 does not require chromatin binding, nor H3K9me3.Iris MüllerAnn Sophie MoroniDaria ShlyuevaSudeep SahadevanErwin M. SchoofAliaksandra RadzisheuskayaJonas W. HøjfeldtTülin TatarRichard P. KocheChang HuangKristian HelinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Iris Müller Ann Sophie Moroni Daria Shlyueva Sudeep Sahadevan Erwin M. Schoof Aliaksandra Radzisheuskaya Jonas W. Højfeldt Tülin Tatar Richard P. Koche Chang Huang Kristian Helin MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells
description	Naïve pluripotency is characterized by distinctly open chromatin and repressed endogenous retroviruses. Here the authors show that MPP8 and its association with the core HUSH complex is essential for naïve pluripotent cells; also that repression of LINE1 elements by MPP8 does not require chromatin binding, nor H3K9me3.
format	article
author	Iris Müller Ann Sophie Moroni Daria Shlyueva Sudeep Sahadevan Erwin M. Schoof Aliaksandra Radzisheuskaya Jonas W. Højfeldt Tülin Tatar Richard P. Koche Chang Huang Kristian Helin
author_facet	Iris Müller Ann Sophie Moroni Daria Shlyueva Sudeep Sahadevan Erwin M. Schoof Aliaksandra Radzisheuskaya Jonas W. Højfeldt Tülin Tatar Richard P. Koche Chang Huang Kristian Helin
author_sort	Iris Müller
title	MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells
title_short	MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells
title_full	MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells
title_fullStr	MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells
title_full_unstemmed	MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells
title_sort	mpp8 is essential for sustaining self-renewal of ground-state pluripotent stem cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9597bd4ec7404890a76dbc8df6a59f5c
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MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells

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