MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells

MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells

Naïve pluripotency is characterized by distinctly open chromatin and repressed endogenous retroviruses. Here the authors show that MPP8 and its association with the core HUSH complex is essential for naïve pluripotent cells; also that repression of LINE1 elements by MPP8 does not require chromatin b...

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Autores principales: Iris Müller, Ann Sophie Moroni, Daria Shlyueva, Sudeep Sahadevan, Erwin M. Schoof, Aliaksandra Radzisheuskaya, Jonas W. Højfeldt, Tülin Tatar, Richard P. Koche, Chang Huang, Kristian Helin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/9597bd4ec7404890a76dbc8df6a59f5c
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