3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine
3-hydroxy-L-kynurenamine (3-HKA) is a metabolite deriving from a lateral pathway of tryptophan catabolism. Here the authors identify 3-HKA as a biogenic amine and show it has anti-inflammatory properties that can protect mice against psoriasis and nephrotoxic nephritis.
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Nature Portfolio
2021
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oai:doaj.org-article:95a6bc7fc7a345f08d833daae479ee942021-12-02T17:57:04Z3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine10.1038/s41467-021-24785-32041-1723https://doaj.org/article/95a6bc7fc7a345f08d833daae479ee942021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24785-3https://doaj.org/toc/2041-17233-hydroxy-L-kynurenamine (3-HKA) is a metabolite deriving from a lateral pathway of tryptophan catabolism. Here the authors identify 3-HKA as a biogenic amine and show it has anti-inflammatory properties that can protect mice against psoriasis and nephrotoxic nephritis.Cristina C. ClementAngelo D’AlessandroSangeetha ThangaswamySamantha ChalmersRaquel FurtadoSheila SpadaGiada MondanelliFederica IanniSarah GehrkeMarco GargaroGiorgia ManniLuisa Carlota Lopez CaraPeter RungeWanxia Li TsaiSinem KaramanJorge ArasaRuben Fernandez-RodriguezAmanda BeckAntonio MacchiaruloMassimo GadinaCornelia HalinFrancesca FallarinoMihaela SkobeMarc VeldhoenSimone MorettiSilvia FormentiSandra DemariaRajesh K. SoniRoberta GalariniRoccaldo SardellaGregoire LauvauChaim PuttermanKari AlitaloUrsula GrohmannLaura SantambrogioNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
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DOAJ |
| language |
EN |
| topic |
Science Q |
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Science Q Cristina C. Clement Angelo D’Alessandro Sangeetha Thangaswamy Samantha Chalmers Raquel Furtado Sheila Spada Giada Mondanelli Federica Ianni Sarah Gehrke Marco Gargaro Giorgia Manni Luisa Carlota Lopez Cara Peter Runge Wanxia Li Tsai Sinem Karaman Jorge Arasa Ruben Fernandez-Rodriguez Amanda Beck Antonio Macchiarulo Massimo Gadina Cornelia Halin Francesca Fallarino Mihaela Skobe Marc Veldhoen Simone Moretti Silvia Formenti Sandra Demaria Rajesh K. Soni Roberta Galarini Roccaldo Sardella Gregoire Lauvau Chaim Putterman Kari Alitalo Ursula Grohmann Laura Santambrogio 3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine |
| description |
3-hydroxy-L-kynurenamine (3-HKA) is a metabolite deriving from a lateral pathway of tryptophan catabolism. Here the authors identify 3-HKA as a biogenic amine and show it has anti-inflammatory properties that can protect mice against psoriasis and nephrotoxic nephritis. |
| format |
article |
| author |
Cristina C. Clement Angelo D’Alessandro Sangeetha Thangaswamy Samantha Chalmers Raquel Furtado Sheila Spada Giada Mondanelli Federica Ianni Sarah Gehrke Marco Gargaro Giorgia Manni Luisa Carlota Lopez Cara Peter Runge Wanxia Li Tsai Sinem Karaman Jorge Arasa Ruben Fernandez-Rodriguez Amanda Beck Antonio Macchiarulo Massimo Gadina Cornelia Halin Francesca Fallarino Mihaela Skobe Marc Veldhoen Simone Moretti Silvia Formenti Sandra Demaria Rajesh K. Soni Roberta Galarini Roccaldo Sardella Gregoire Lauvau Chaim Putterman Kari Alitalo Ursula Grohmann Laura Santambrogio |
| author_facet |
Cristina C. Clement Angelo D’Alessandro Sangeetha Thangaswamy Samantha Chalmers Raquel Furtado Sheila Spada Giada Mondanelli Federica Ianni Sarah Gehrke Marco Gargaro Giorgia Manni Luisa Carlota Lopez Cara Peter Runge Wanxia Li Tsai Sinem Karaman Jorge Arasa Ruben Fernandez-Rodriguez Amanda Beck Antonio Macchiarulo Massimo Gadina Cornelia Halin Francesca Fallarino Mihaela Skobe Marc Veldhoen Simone Moretti Silvia Formenti Sandra Demaria Rajesh K. Soni Roberta Galarini Roccaldo Sardella Gregoire Lauvau Chaim Putterman Kari Alitalo Ursula Grohmann Laura Santambrogio |
| author_sort |
Cristina C. Clement |
| title |
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine |
| title_short |
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine |
| title_full |
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine |
| title_fullStr |
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine |
| title_full_unstemmed |
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine |
| title_sort |
3-hydroxy-l-kynurenamine is an immunomodulatory biogenic amine |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/95a6bc7fc7a345f08d833daae479ee94 |
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