Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIα and Oxysterol-Binding Protein

Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIα and Oxysterol-Binding Protein

ABSTRACT Positive-strand RNA [(+)RNA] viruses are true masters of reprogramming host lipid trafficking and synthesis to support virus genome replication. Via their membrane-associated 3A protein, picornaviruses of the genus Enterovirus (e.g., poliovirus, coxsackievirus, and rhinovirus) subvert Golgi...

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Autores principales: Cristina M. Dorobantu, Lucian Albulescu, Heyrhyoung Lyoo, Mirjam van Kampen, Raffaele De Francesco, Volker Lohmann, Christian Harak, Hilde M. van der Schaar, Jeroen R. P. M. Strating, Alexander E. Gorbalenya, Frank J. M. van Kuppeveld
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2016
Materias:
EMCV
OSBP
PI4KA
PI4P
cholesterol
mutants
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/95a6ee69959a49289b7cdb53a02feac5
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https://doaj.org/article/95a6ee69959a49289b7cdb53a02feac5

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