Sex determining region Y-box 2 (SOX2) amplification is an independent indicator of disease recurrence in sinonasal cancer.

<h4>Objectives</h4>The transcription factor SOX2 (3q26.3-q27) is an embryonic stem cell factor contributing to the induction of pluripotency in terminally differentiated somatic cells. Recently, amplification of the SOX2 gene locus has been described in squamous cell carcinoma (SCC) of d...

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Autores principales: Andreas Schröck, Friederike Göke, Patrick Wagner, Maike Bode, Alina Franzen, Martin Braun, Sebastian Huss, Abbas Agaimy, Stephan Ihrler, Ropika Menon, Robert Kirsten, Glen Kristiansen, Friedrich Bootz, Claudia Lengerke, Sven Perner
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Publicado: Public Library of Science (PLoS) 2013
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spelling oai:doaj.org-article:95ac521457af477c8b19995ce451261d2021-11-18T07:51:49ZSex determining region Y-box 2 (SOX2) amplification is an independent indicator of disease recurrence in sinonasal cancer.1932-620310.1371/journal.pone.0059201https://doaj.org/article/95ac521457af477c8b19995ce451261d2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23544055/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4>The transcription factor SOX2 (3q26.3-q27) is an embryonic stem cell factor contributing to the induction of pluripotency in terminally differentiated somatic cells. Recently, amplification of the SOX2 gene locus has been described in squamous cell carcinoma (SCC) of different organ sites. Aim of this study was to investigate amplification and expression status of SOX2 in sinonasal carcinomas and to correlate the results with clinico-pathological data.<h4>Materials and methods</h4>A total of 119 primary tumor samples from the sinonasal region were assessed by fluorescence in-situ hybridization and immunohistochemistry for SOX2 gene amplification and protein expression, respectively. Of these, 59 were SSCs, 18 sinonasal undifferentiated carcinomas (SNUC), 10 carcinomas associated with an inverted papilloma (INVC), 19 adenocarcinomas (AD) and 13 adenoid cystic carcinomas (ACC).<h4>Results</h4>SOX2 amplifications were found in subsets of SCCs (37.5%), SNUCs (35.3%), INVCs (37.5%) and ADs (8.3%) but not in ACCs. SOX2 amplification resulted in increased protein expression. Patients with SOX2-amplified sinonasal carcinomas showed a significantly higher rate of tumor recurrences than SOX2 non-amplified tumors.<h4>Conclusion</h4>This is the first study assessing SOX2 amplification and expression in a large cohort of sinonasal carcinomas. As opposed to AD and ACC, SOX2 amplifications were detected in more than 1/3 of all SCCs, SNUCs and INVCs. We therefore suggest that SNUCs are molecularly closely related to SCCs and INVCs and that these entities represent a subgroup of sinonasal carcinomas relying on SOX2 acquisition during oncogenesis. SOX2 amplification appears to identify sinonasal carcinomas that are more likely to relapse after primary therapy, suggesting that these patients might benefit from a more aggressive therapy regime.Andreas SchröckFriederike GökePatrick WagnerMaike BodeAlina FranzenMartin BraunSebastian HussAbbas AgaimyStephan IhrlerRopika MenonRobert KirstenGlen KristiansenFriedrich BootzClaudia LengerkeSven PernerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e59201 (2013)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Andreas Schröck
Friederike Göke
Patrick Wagner
Maike Bode
Alina Franzen
Martin Braun
Sebastian Huss
Abbas Agaimy
Stephan Ihrler
Ropika Menon
Robert Kirsten
Glen Kristiansen
Friedrich Bootz
Claudia Lengerke
Sven Perner
Sex determining region Y-box 2 (SOX2) amplification is an independent indicator of disease recurrence in sinonasal cancer.
description <h4>Objectives</h4>The transcription factor SOX2 (3q26.3-q27) is an embryonic stem cell factor contributing to the induction of pluripotency in terminally differentiated somatic cells. Recently, amplification of the SOX2 gene locus has been described in squamous cell carcinoma (SCC) of different organ sites. Aim of this study was to investigate amplification and expression status of SOX2 in sinonasal carcinomas and to correlate the results with clinico-pathological data.<h4>Materials and methods</h4>A total of 119 primary tumor samples from the sinonasal region were assessed by fluorescence in-situ hybridization and immunohistochemistry for SOX2 gene amplification and protein expression, respectively. Of these, 59 were SSCs, 18 sinonasal undifferentiated carcinomas (SNUC), 10 carcinomas associated with an inverted papilloma (INVC), 19 adenocarcinomas (AD) and 13 adenoid cystic carcinomas (ACC).<h4>Results</h4>SOX2 amplifications were found in subsets of SCCs (37.5%), SNUCs (35.3%), INVCs (37.5%) and ADs (8.3%) but not in ACCs. SOX2 amplification resulted in increased protein expression. Patients with SOX2-amplified sinonasal carcinomas showed a significantly higher rate of tumor recurrences than SOX2 non-amplified tumors.<h4>Conclusion</h4>This is the first study assessing SOX2 amplification and expression in a large cohort of sinonasal carcinomas. As opposed to AD and ACC, SOX2 amplifications were detected in more than 1/3 of all SCCs, SNUCs and INVCs. We therefore suggest that SNUCs are molecularly closely related to SCCs and INVCs and that these entities represent a subgroup of sinonasal carcinomas relying on SOX2 acquisition during oncogenesis. SOX2 amplification appears to identify sinonasal carcinomas that are more likely to relapse after primary therapy, suggesting that these patients might benefit from a more aggressive therapy regime.
format article
author Andreas Schröck
Friederike Göke
Patrick Wagner
Maike Bode
Alina Franzen
Martin Braun
Sebastian Huss
Abbas Agaimy
Stephan Ihrler
Ropika Menon
Robert Kirsten
Glen Kristiansen
Friedrich Bootz
Claudia Lengerke
Sven Perner
author_facet Andreas Schröck
Friederike Göke
Patrick Wagner
Maike Bode
Alina Franzen
Martin Braun
Sebastian Huss
Abbas Agaimy
Stephan Ihrler
Ropika Menon
Robert Kirsten
Glen Kristiansen
Friedrich Bootz
Claudia Lengerke
Sven Perner
author_sort Andreas Schröck
title Sex determining region Y-box 2 (SOX2) amplification is an independent indicator of disease recurrence in sinonasal cancer.
title_short Sex determining region Y-box 2 (SOX2) amplification is an independent indicator of disease recurrence in sinonasal cancer.
title_full Sex determining region Y-box 2 (SOX2) amplification is an independent indicator of disease recurrence in sinonasal cancer.
title_fullStr Sex determining region Y-box 2 (SOX2) amplification is an independent indicator of disease recurrence in sinonasal cancer.
title_full_unstemmed Sex determining region Y-box 2 (SOX2) amplification is an independent indicator of disease recurrence in sinonasal cancer.
title_sort sex determining region y-box 2 (sox2) amplification is an independent indicator of disease recurrence in sinonasal cancer.
publisher Public Library of Science (PLoS)
publishDate 2013
url https://doaj.org/article/95ac521457af477c8b19995ce451261d
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