T-cell stimuli independently sum to regulate an inherited clonal division fate

Why do populations of highly similar T cells have heterogeneous division destinies in response to antigenic stimulus? Here the authors develop a multiplex-dye assay and a mathematical framework to test clonal heterogeneity and show distinction in division destiny is a result of inter-clonal variabil...

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Autores principales:	J. M. Marchingo, G. Prevedello, A. Kan, S. Heinzel, P. D. Hodgkin, K. R. Duffy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/95b6391d198249d286ba54ffd85a581c
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spelling	oai:doaj.org-article:95b6391d198249d286ba54ffd85a581c2021-12-02T16:50:15ZT-cell stimuli independently sum to regulate an inherited clonal division fate10.1038/ncomms135402041-1723https://doaj.org/article/95b6391d198249d286ba54ffd85a581c2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13540https://doaj.org/toc/2041-1723Why do populations of highly similar T cells have heterogeneous division destinies in response to antigenic stimulus? Here the authors develop a multiplex-dye assay and a mathematical framework to test clonal heterogeneity and show distinction in division destiny is a result of inter-clonal variability as lineage imprinting ensures clones share similar proliferation fates.J. M. MarchingoG. PrevedelloA. KanS. HeinzelP. D. HodgkinK. R. DuffyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q J. M. Marchingo G. Prevedello A. Kan S. Heinzel P. D. Hodgkin K. R. Duffy T-cell stimuli independently sum to regulate an inherited clonal division fate
description	Why do populations of highly similar T cells have heterogeneous division destinies in response to antigenic stimulus? Here the authors develop a multiplex-dye assay and a mathematical framework to test clonal heterogeneity and show distinction in division destiny is a result of inter-clonal variability as lineage imprinting ensures clones share similar proliferation fates.
format	article
author	J. M. Marchingo G. Prevedello A. Kan S. Heinzel P. D. Hodgkin K. R. Duffy
author_facet	J. M. Marchingo G. Prevedello A. Kan S. Heinzel P. D. Hodgkin K. R. Duffy
author_sort	J. M. Marchingo
title	T-cell stimuli independently sum to regulate an inherited clonal division fate
title_short	T-cell stimuli independently sum to regulate an inherited clonal division fate
title_full	T-cell stimuli independently sum to regulate an inherited clonal division fate
title_fullStr	T-cell stimuli independently sum to regulate an inherited clonal division fate
title_full_unstemmed	T-cell stimuli independently sum to regulate an inherited clonal division fate
title_sort	t-cell stimuli independently sum to regulate an inherited clonal division fate
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/95b6391d198249d286ba54ffd85a581c
work_keys_str_mv	AT jmmarchingo tcellstimuliindependentlysumtoregulateaninheritedclonaldivisionfate AT gprevedello tcellstimuliindependentlysumtoregulateaninheritedclonaldivisionfate AT akan tcellstimuliindependentlysumtoregulateaninheritedclonaldivisionfate AT sheinzel tcellstimuliindependentlysumtoregulateaninheritedclonaldivisionfate AT pdhodgkin tcellstimuliindependentlysumtoregulateaninheritedclonaldivisionfate AT krduffy tcellstimuliindependentlysumtoregulateaninheritedclonaldivisionfate
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T-cell stimuli independently sum to regulate an inherited clonal division fate

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