NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence

During wound healing and infection in the skin there is a hypoxic environment involving HIF-1α and NK cells. Here the authors show that NK cells through HIF-1α provide a cross-regulatory balance to provide an adequate antimicrobial defence that can inhibit subsequent wound healing.

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Autores principales:	Michal Sobecki, Ewelina Krzywinska, Shunmugam Nagarajan, Annette Audigé, Khanh Huỳnh, Julian Zacharjasz, Julien Debbache, Yann Kerdiles, Dagmar Gotthardt, Norihiko Takeda, Joachim Fandrey, Lukas Sommer, Veronika Sexl, Christian Stockmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/95b70bae74314a89afad5e46b3247257
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:95b70bae74314a89afad5e46b32472572021-12-02T18:49:37ZNK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence10.1038/s41467-021-25065-w2041-1723https://doaj.org/article/95b70bae74314a89afad5e46b32472572021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25065-whttps://doaj.org/toc/2041-1723During wound healing and infection in the skin there is a hypoxic environment involving HIF-1α and NK cells. Here the authors show that NK cells through HIF-1α provide a cross-regulatory balance to provide an adequate antimicrobial defence that can inhibit subsequent wound healing.Michal SobeckiEwelina KrzywinskaShunmugam NagarajanAnnette AudigéKhanh HuỳnhJulian ZacharjaszJulien DebbacheYann KerdilesDagmar GotthardtNorihiko TakedaJoachim FandreyLukas SommerVeronika SexlChristian StockmannNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michal Sobecki Ewelina Krzywinska Shunmugam Nagarajan Annette Audigé Khanh Huỳnh Julian Zacharjasz Julien Debbache Yann Kerdiles Dagmar Gotthardt Norihiko Takeda Joachim Fandrey Lukas Sommer Veronika Sexl Christian Stockmann NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence
description	During wound healing and infection in the skin there is a hypoxic environment involving HIF-1α and NK cells. Here the authors show that NK cells through HIF-1α provide a cross-regulatory balance to provide an adequate antimicrobial defence that can inhibit subsequent wound healing.
format	article
author	Michal Sobecki Ewelina Krzywinska Shunmugam Nagarajan Annette Audigé Khanh Huỳnh Julian Zacharjasz Julien Debbache Yann Kerdiles Dagmar Gotthardt Norihiko Takeda Joachim Fandrey Lukas Sommer Veronika Sexl Christian Stockmann
author_facet	Michal Sobecki Ewelina Krzywinska Shunmugam Nagarajan Annette Audigé Khanh Huỳnh Julian Zacharjasz Julien Debbache Yann Kerdiles Dagmar Gotthardt Norihiko Takeda Joachim Fandrey Lukas Sommer Veronika Sexl Christian Stockmann
author_sort	Michal Sobecki
title	NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence
title_short	NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence
title_full	NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence
title_fullStr	NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence
title_full_unstemmed	NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence
title_sort	nk cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/95b70bae74314a89afad5e46b3247257
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NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence

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