Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity

The secretome from cancer and stromal cells contributes to the creation of a microenvironment, which in turn contributes to invasion and angiogenesis. Here, the authors compare the secretomes of immortalized normal fibroblasts and cancer-derived fibroblast and identify CLIC3 as a driver of cancer pr...

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Autores principales:	Juan R. Hernandez-Fernaud, Elena Ruengeler, Andrea Casazza, Lisa J. Neilson, Ellie Pulleine, Alice Santi, Shehab Ismail, Sergio Lilla, Sandeep Dhayade, Iain R. MacPherson, Iain McNeish, Darren Ennis, Hala Ali, Fernanda G. Kugeratski, Heba Al Khamici, Maartje van den Biggelaar, Peter V.E. van den Berghe, Catherine Cloix, Laura McDonald, David Millan, Aoisha Hoyle, Anna Kuchnio, Peter Carmeliet, Stella M. Valenzuela, Karen Blyth, Huabing Yin, Massimiliano Mazzone, Jim C. Norman, Sara Zanivan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/95c1f45d24284070873d0d702ce64647
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spelling	oai:doaj.org-article:95c1f45d24284070873d0d702ce646472021-12-02T17:06:03ZSecreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity10.1038/ncomms142062041-1723https://doaj.org/article/95c1f45d24284070873d0d702ce646472017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14206https://doaj.org/toc/2041-1723The secretome from cancer and stromal cells contributes to the creation of a microenvironment, which in turn contributes to invasion and angiogenesis. Here, the authors compare the secretomes of immortalized normal fibroblasts and cancer-derived fibroblast and identify CLIC3 as a driver of cancer progression.Juan R. Hernandez-FernaudElena RuengelerAndrea CasazzaLisa J. NeilsonEllie PulleineAlice SantiShehab IsmailSergio LillaSandeep DhayadeIain R. MacPhersonIain McNeishDarren EnnisHala AliFernanda G. KugeratskiHeba Al KhamiciMaartje van den BiggelaarPeter V.E. van den BergheCatherine CloixLaura McDonaldDavid MillanAoisha HoyleAnna KuchnioPeter CarmelietStella M. ValenzuelaKaren BlythHuabing YinMassimiliano MazzoneJim C. NormanSara ZanivanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Juan R. Hernandez-Fernaud Elena Ruengeler Andrea Casazza Lisa J. Neilson Ellie Pulleine Alice Santi Shehab Ismail Sergio Lilla Sandeep Dhayade Iain R. MacPherson Iain McNeish Darren Ennis Hala Ali Fernanda G. Kugeratski Heba Al Khamici Maartje van den Biggelaar Peter V.E. van den Berghe Catherine Cloix Laura McDonald David Millan Aoisha Hoyle Anna Kuchnio Peter Carmeliet Stella M. Valenzuela Karen Blyth Huabing Yin Massimiliano Mazzone Jim C. Norman Sara Zanivan Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity
description	The secretome from cancer and stromal cells contributes to the creation of a microenvironment, which in turn contributes to invasion and angiogenesis. Here, the authors compare the secretomes of immortalized normal fibroblasts and cancer-derived fibroblast and identify CLIC3 as a driver of cancer progression.
format	article
author	Juan R. Hernandez-Fernaud Elena Ruengeler Andrea Casazza Lisa J. Neilson Ellie Pulleine Alice Santi Shehab Ismail Sergio Lilla Sandeep Dhayade Iain R. MacPherson Iain McNeish Darren Ennis Hala Ali Fernanda G. Kugeratski Heba Al Khamici Maartje van den Biggelaar Peter V.E. van den Berghe Catherine Cloix Laura McDonald David Millan Aoisha Hoyle Anna Kuchnio Peter Carmeliet Stella M. Valenzuela Karen Blyth Huabing Yin Massimiliano Mazzone Jim C. Norman Sara Zanivan
author_facet	Juan R. Hernandez-Fernaud Elena Ruengeler Andrea Casazza Lisa J. Neilson Ellie Pulleine Alice Santi Shehab Ismail Sergio Lilla Sandeep Dhayade Iain R. MacPherson Iain McNeish Darren Ennis Hala Ali Fernanda G. Kugeratski Heba Al Khamici Maartje van den Biggelaar Peter V.E. van den Berghe Catherine Cloix Laura McDonald David Millan Aoisha Hoyle Anna Kuchnio Peter Carmeliet Stella M. Valenzuela Karen Blyth Huabing Yin Massimiliano Mazzone Jim C. Norman Sara Zanivan
author_sort	Juan R. Hernandez-Fernaud
title	Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity
title_short	Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity
title_full	Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity
title_fullStr	Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity
title_full_unstemmed	Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity
title_sort	secreted clic3 drives cancer progression through its glutathione-dependent oxidoreductase activity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/95c1f45d24284070873d0d702ce64647
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Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity

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