Large‐scale genomic sequencing reveals adaptive opportunity of targeting mutated‐PI3Kα in early and advanced HER2‐positive breast cancer

Abstract Background Few studies have discussed the contradictory roles of mutated‐PI3Kα in HER2‐positive (HER2+) breast cancer. Thus, we characterised the adaptive roles of PI3Kα mutations among HER2+ tumour progression. Methods We conducted prospective clinical sequencing of 1923 Chinese breast can...

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Autores principales: Lin‐Wei Guo, Xiao‐Guang Li, Yun‐Song Yang, Xun‐Xi Lu, Xiang‐Chen Han, Guan‐Tian Lang, Li Chen, Zhi‐Ming Shao, Xin Hu
Formato: article
Lenguaje:EN
Publicado: Wiley 2021
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Acceso en línea:https://doaj.org/article/95e5f690bc48412b8e7f6cd96e0d6269
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