Desymmetrization of meso-bisphosphates using copper catalysis and alkylzirconocene nucleophiles

Copper-catalyzed allylic desymmetrizations are, so far, limited to carbocyclic products with two tertiary stereocenters. Here, the authors report a highly enantioselective Cu-catalyzed desymmetrization of meso carbo- and hetero-cyclic bisphosphates to give products with up to three contiguous stereo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Reece Jacques, Robert D. C. Pullin, Stephen P. Fletcher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/95ed68147a644b96bbf5abd9358e986a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:95ed68147a644b96bbf5abd9358e986a
record_format	dspace
spelling	oai:doaj.org-article:95ed68147a644b96bbf5abd9358e986a2021-12-02T14:35:30ZDesymmetrization of meso-bisphosphates using copper catalysis and alkylzirconocene nucleophiles10.1038/s41467-018-07871-x2041-1723https://doaj.org/article/95ed68147a644b96bbf5abd9358e986a2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07871-xhttps://doaj.org/toc/2041-1723Copper-catalyzed allylic desymmetrizations are, so far, limited to carbocyclic products with two tertiary stereocenters. Here, the authors report a highly enantioselective Cu-catalyzed desymmetrization of meso carbo- and hetero-cyclic bisphosphates to give products with up to three contiguous stereocenters.Reece JacquesRobert D. C. PullinStephen P. FletcherNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-6 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Reece Jacques Robert D. C. Pullin Stephen P. Fletcher Desymmetrization of meso-bisphosphates using copper catalysis and alkylzirconocene nucleophiles
description	Copper-catalyzed allylic desymmetrizations are, so far, limited to carbocyclic products with two tertiary stereocenters. Here, the authors report a highly enantioselective Cu-catalyzed desymmetrization of meso carbo- and hetero-cyclic bisphosphates to give products with up to three contiguous stereocenters.
format	article
author	Reece Jacques Robert D. C. Pullin Stephen P. Fletcher
author_facet	Reece Jacques Robert D. C. Pullin Stephen P. Fletcher
author_sort	Reece Jacques
title	Desymmetrization of meso-bisphosphates using copper catalysis and alkylzirconocene nucleophiles
title_short	Desymmetrization of meso-bisphosphates using copper catalysis and alkylzirconocene nucleophiles
title_full	Desymmetrization of meso-bisphosphates using copper catalysis and alkylzirconocene nucleophiles
title_fullStr	Desymmetrization of meso-bisphosphates using copper catalysis and alkylzirconocene nucleophiles
title_full_unstemmed	Desymmetrization of meso-bisphosphates using copper catalysis and alkylzirconocene nucleophiles
title_sort	desymmetrization of meso-bisphosphates using copper catalysis and alkylzirconocene nucleophiles
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/95ed68147a644b96bbf5abd9358e986a
work_keys_str_mv	AT reecejacques desymmetrizationofmesobisphosphatesusingcoppercatalysisandalkylzirconocenenucleophiles AT robertdcpullin desymmetrizationofmesobisphosphatesusingcoppercatalysisandalkylzirconocenenucleophiles AT stephenpfletcher desymmetrizationofmesobisphosphatesusingcoppercatalysisandalkylzirconocenenucleophiles
_version_	1718391145701048320

Desymmetrization of meso-bisphosphates using copper catalysis and alkylzirconocene nucleophiles

Ejemplares similares