Variant-specific inflation factors for assessing population stratification at the phenotypic variance level

Variant-specific inflation factors for assessing population stratification at the phenotypic variance level

Pooling participant-level genetic data into a single analysis can result in variance stratification, reducing statistical performance. Here, the authors develop variant-specific inflation factors to assess variance stratification and apply this to pooled individual-level data from whole genome seque...

Full description

Saved in:
Bibliographic Details
Main Authors: Tamar Sofer, Xiuwen Zheng, Cecelia A. Laurie, Stephanie M. Gogarten, Jennifer A. Brody, Matthew P. Conomos, Joshua C. Bis, Timothy A. Thornton, Adam Szpiro, Jeffrey R. O’Connell, Ethan M. Lange, Yan Gao, L. Adrienne Cupples, Bruce M. Psaty, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Kenneth M. Rice
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
Q
Online Access:https://doaj.org/article/95ef2a1716c643edaaee931435315164
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/95ef2a1716c643edaaee931435315164

Similar Items