A potent KRAS macromolecule degrader specifically targeting tumours with mutant KRAS

Targeted protein degradation is an attractive therapeutic strategy to deplete oncogenic proteins in tumours. Here the authors demonstrate the specific targeting of endogenous KRAS protein for degradation from cancer cells, and regression of tumours expressing mutant KRAS in a mouse model.

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Detalles Bibliográficos
Autores principales:	Nicolas Bery, Ami Miller, Terry Rabbitts
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/960ac50f46934b108f258aa4907c22dc
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spelling	oai:doaj.org-article:960ac50f46934b108f258aa4907c22dc2021-12-02T16:05:51ZA potent KRAS macromolecule degrader specifically targeting tumours with mutant KRAS10.1038/s41467-020-17022-w2041-1723https://doaj.org/article/960ac50f46934b108f258aa4907c22dc2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17022-whttps://doaj.org/toc/2041-1723Targeted protein degradation is an attractive therapeutic strategy to deplete oncogenic proteins in tumours. Here the authors demonstrate the specific targeting of endogenous KRAS protein for degradation from cancer cells, and regression of tumours expressing mutant KRAS in a mouse model.Nicolas BeryAmi MillerTerry RabbittsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicolas Bery Ami Miller Terry Rabbitts A potent KRAS macromolecule degrader specifically targeting tumours with mutant KRAS
description	Targeted protein degradation is an attractive therapeutic strategy to deplete oncogenic proteins in tumours. Here the authors demonstrate the specific targeting of endogenous KRAS protein for degradation from cancer cells, and regression of tumours expressing mutant KRAS in a mouse model.
format	article
author	Nicolas Bery Ami Miller Terry Rabbitts
author_facet	Nicolas Bery Ami Miller Terry Rabbitts
author_sort	Nicolas Bery
title	A potent KRAS macromolecule degrader specifically targeting tumours with mutant KRAS
title_short	A potent KRAS macromolecule degrader specifically targeting tumours with mutant KRAS
title_full	A potent KRAS macromolecule degrader specifically targeting tumours with mutant KRAS
title_fullStr	A potent KRAS macromolecule degrader specifically targeting tumours with mutant KRAS
title_full_unstemmed	A potent KRAS macromolecule degrader specifically targeting tumours with mutant KRAS
title_sort	potent kras macromolecule degrader specifically targeting tumours with mutant kras
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/960ac50f46934b108f258aa4907c22dc
work_keys_str_mv	AT nicolasbery apotentkrasmacromoleculedegraderspecificallytargetingtumourswithmutantkras AT amimiller apotentkrasmacromoleculedegraderspecificallytargetingtumourswithmutantkras AT terryrabbitts apotentkrasmacromoleculedegraderspecificallytargetingtumourswithmutantkras AT nicolasbery potentkrasmacromoleculedegraderspecificallytargetingtumourswithmutantkras AT amimiller potentkrasmacromoleculedegraderspecificallytargetingtumourswithmutantkras AT terryrabbitts potentkrasmacromoleculedegraderspecificallytargetingtumourswithmutantkras
_version_	1718385162578821120

A potent KRAS macromolecule degrader specifically targeting tumours with mutant KRAS

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