Immuno-genomic landscape of osteosarcoma

The efficacy of immune checkpoint inhibitors (ICI) in osteosarcoma has been limited. Here, the authors investigate the immunogenomic landscape of osteosarcoma, and integrated analyses highlight features related to a suppressed immune microenvironment.

Guardado en:

Detalles Bibliográficos
Autores principales:	Chia-Chin Wu, Hannah C. Beird, J. Andrew Livingston, Shailesh Advani, Akash Mitra, Shaolong Cao, Alexandre Reuben, Davis Ingram, Wei-Lien Wang, Zhenlin Ju, Cheuk Hong Leung, Heather Lin, Youyun Zheng, Jason Roszik, Wenyi Wang, Shreyaskumar Patel, Robert S. Benjamin, Neeta Somaiah, Anthony P. Conley, Gordon B. Mills, Patrick Hwu, Richard Gorlick, Alexander Lazar, Najat C. Daw, Valerae Lewis, P. Andrew Futreal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9625ce655ae742c48c06ec6ccd628544
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9625ce655ae742c48c06ec6ccd628544
record_format	dspace
spelling	oai:doaj.org-article:9625ce655ae742c48c06ec6ccd6285442021-12-02T17:31:54ZImmuno-genomic landscape of osteosarcoma10.1038/s41467-020-14646-w2041-1723https://doaj.org/article/9625ce655ae742c48c06ec6ccd6285442020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14646-whttps://doaj.org/toc/2041-1723The efficacy of immune checkpoint inhibitors (ICI) in osteosarcoma has been limited. Here, the authors investigate the immunogenomic landscape of osteosarcoma, and integrated analyses highlight features related to a suppressed immune microenvironment.Chia-Chin WuHannah C. BeirdJ. Andrew LivingstonShailesh AdvaniAkash MitraShaolong CaoAlexandre ReubenDavis IngramWei-Lien WangZhenlin JuCheuk Hong LeungHeather LinYouyun ZhengJason RoszikWenyi WangShreyaskumar PatelRobert S. BenjaminNeeta SomaiahAnthony P. ConleyGordon B. MillsPatrick HwuRichard GorlickAlexander LazarNajat C. DawValerae LewisP. Andrew FutrealNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chia-Chin Wu Hannah C. Beird J. Andrew Livingston Shailesh Advani Akash Mitra Shaolong Cao Alexandre Reuben Davis Ingram Wei-Lien Wang Zhenlin Ju Cheuk Hong Leung Heather Lin Youyun Zheng Jason Roszik Wenyi Wang Shreyaskumar Patel Robert S. Benjamin Neeta Somaiah Anthony P. Conley Gordon B. Mills Patrick Hwu Richard Gorlick Alexander Lazar Najat C. Daw Valerae Lewis P. Andrew Futreal Immuno-genomic landscape of osteosarcoma
description	The efficacy of immune checkpoint inhibitors (ICI) in osteosarcoma has been limited. Here, the authors investigate the immunogenomic landscape of osteosarcoma, and integrated analyses highlight features related to a suppressed immune microenvironment.
format	article
author	Chia-Chin Wu Hannah C. Beird J. Andrew Livingston Shailesh Advani Akash Mitra Shaolong Cao Alexandre Reuben Davis Ingram Wei-Lien Wang Zhenlin Ju Cheuk Hong Leung Heather Lin Youyun Zheng Jason Roszik Wenyi Wang Shreyaskumar Patel Robert S. Benjamin Neeta Somaiah Anthony P. Conley Gordon B. Mills Patrick Hwu Richard Gorlick Alexander Lazar Najat C. Daw Valerae Lewis P. Andrew Futreal
author_facet	Chia-Chin Wu Hannah C. Beird J. Andrew Livingston Shailesh Advani Akash Mitra Shaolong Cao Alexandre Reuben Davis Ingram Wei-Lien Wang Zhenlin Ju Cheuk Hong Leung Heather Lin Youyun Zheng Jason Roszik Wenyi Wang Shreyaskumar Patel Robert S. Benjamin Neeta Somaiah Anthony P. Conley Gordon B. Mills Patrick Hwu Richard Gorlick Alexander Lazar Najat C. Daw Valerae Lewis P. Andrew Futreal
author_sort	Chia-Chin Wu
title	Immuno-genomic landscape of osteosarcoma
title_short	Immuno-genomic landscape of osteosarcoma
title_full	Immuno-genomic landscape of osteosarcoma
title_fullStr	Immuno-genomic landscape of osteosarcoma
title_full_unstemmed	Immuno-genomic landscape of osteosarcoma
title_sort	immuno-genomic landscape of osteosarcoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9625ce655ae742c48c06ec6ccd628544
work_keys_str_mv	AT chiachinwu immunogenomiclandscapeofosteosarcoma AT hannahcbeird immunogenomiclandscapeofosteosarcoma AT jandrewlivingston immunogenomiclandscapeofosteosarcoma AT shaileshadvani immunogenomiclandscapeofosteosarcoma AT akashmitra immunogenomiclandscapeofosteosarcoma AT shaolongcao immunogenomiclandscapeofosteosarcoma AT alexandrereuben immunogenomiclandscapeofosteosarcoma AT davisingram immunogenomiclandscapeofosteosarcoma AT weilienwang immunogenomiclandscapeofosteosarcoma AT zhenlinju immunogenomiclandscapeofosteosarcoma AT cheukhongleung immunogenomiclandscapeofosteosarcoma AT heatherlin immunogenomiclandscapeofosteosarcoma AT youyunzheng immunogenomiclandscapeofosteosarcoma AT jasonroszik immunogenomiclandscapeofosteosarcoma AT wenyiwang immunogenomiclandscapeofosteosarcoma AT shreyaskumarpatel immunogenomiclandscapeofosteosarcoma AT robertsbenjamin immunogenomiclandscapeofosteosarcoma AT neetasomaiah immunogenomiclandscapeofosteosarcoma AT anthonypconley immunogenomiclandscapeofosteosarcoma AT gordonbmills immunogenomiclandscapeofosteosarcoma AT patrickhwu immunogenomiclandscapeofosteosarcoma AT richardgorlick immunogenomiclandscapeofosteosarcoma AT alexanderlazar immunogenomiclandscapeofosteosarcoma AT najatcdaw immunogenomiclandscapeofosteosarcoma AT valeraelewis immunogenomiclandscapeofosteosarcoma AT pandrewfutreal immunogenomiclandscapeofosteosarcoma
_version_	1718380442979139584

Immuno-genomic landscape of osteosarcoma

Ejemplares similares