Late-stage trifluoromethylthiolation of benzylic C-H bonds

Fluoroalkylation of C-H bonds is a class of reaction highly sought after in medicinal chemistry. Here, the authors report a regioselective organophotoredox-catalyzed, trifluoromethylthiolation of benzylic C-H bonds for a wide variety of alkyl (hetero)arenes, and demonstrate its utility in continuous...

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Autores principales: Wentao Xu, Wenliang Wang, Tao Liu, Jin Xie, Chengjian Zhu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/962eeabac799400c90079a016c0f307b
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