Late-stage trifluoromethylthiolation of benzylic C-H bonds

Fluoroalkylation of C-H bonds is a class of reaction highly sought after in medicinal chemistry. Here, the authors report a regioselective organophotoredox-catalyzed, trifluoromethylthiolation of benzylic C-H bonds for a wide variety of alkyl (hetero)arenes, and demonstrate its utility in continuous...

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Autores principales:	Wentao Xu, Wenliang Wang, Tao Liu, Jin Xie, Chengjian Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/962eeabac799400c90079a016c0f307b
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spelling	oai:doaj.org-article:962eeabac799400c90079a016c0f307b2021-12-02T15:36:04ZLate-stage trifluoromethylthiolation of benzylic C-H bonds10.1038/s41467-019-12844-92041-1723https://doaj.org/article/962eeabac799400c90079a016c0f307b2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12844-9https://doaj.org/toc/2041-1723Fluoroalkylation of C-H bonds is a class of reaction highly sought after in medicinal chemistry. Here, the authors report a regioselective organophotoredox-catalyzed, trifluoromethylthiolation of benzylic C-H bonds for a wide variety of alkyl (hetero)arenes, and demonstrate its utility in continuous flow.Wentao XuWenliang WangTao LiuJin XieChengjian ZhuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wentao Xu Wenliang Wang Tao Liu Jin Xie Chengjian Zhu Late-stage trifluoromethylthiolation of benzylic C-H bonds
description	Fluoroalkylation of C-H bonds is a class of reaction highly sought after in medicinal chemistry. Here, the authors report a regioselective organophotoredox-catalyzed, trifluoromethylthiolation of benzylic C-H bonds for a wide variety of alkyl (hetero)arenes, and demonstrate its utility in continuous flow.
format	article
author	Wentao Xu Wenliang Wang Tao Liu Jin Xie Chengjian Zhu
author_facet	Wentao Xu Wenliang Wang Tao Liu Jin Xie Chengjian Zhu
author_sort	Wentao Xu
title	Late-stage trifluoromethylthiolation of benzylic C-H bonds
title_short	Late-stage trifluoromethylthiolation of benzylic C-H bonds
title_full	Late-stage trifluoromethylthiolation of benzylic C-H bonds
title_fullStr	Late-stage trifluoromethylthiolation of benzylic C-H bonds
title_full_unstemmed	Late-stage trifluoromethylthiolation of benzylic C-H bonds
title_sort	late-stage trifluoromethylthiolation of benzylic c-h bonds
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/962eeabac799400c90079a016c0f307b
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Late-stage trifluoromethylthiolation of benzylic C-H bonds

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