Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death

The transcription termination factor Rho is essential for growth in some bacteria but not in others. Here, Botellaet al. show that Rho inactivation causes extensive pervasive transcription and loss of viability of the pathogen Mycobacterium tuberculosis both in vitroand in a mouse model of infection...

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Autores principales:	Laure Botella, Julien Vaubourgeix, Jonathan Livny, Dirk Schnappinger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/968cbdf5c5e643a4b7caa914f7812f41
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spelling	oai:doaj.org-article:968cbdf5c5e643a4b7caa914f7812f412021-12-02T14:41:21ZDepleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death10.1038/ncomms147312041-1723https://doaj.org/article/968cbdf5c5e643a4b7caa914f7812f412017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14731https://doaj.org/toc/2041-1723The transcription termination factor Rho is essential for growth in some bacteria but not in others. Here, Botellaet al. show that Rho inactivation causes extensive pervasive transcription and loss of viability of the pathogen Mycobacterium tuberculosis both in vitroand in a mouse model of infection.Laure BotellaJulien VaubourgeixJonathan LivnyDirk SchnappingerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laure Botella Julien Vaubourgeix Jonathan Livny Dirk Schnappinger Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death
description	The transcription termination factor Rho is essential for growth in some bacteria but not in others. Here, Botellaet al. show that Rho inactivation causes extensive pervasive transcription and loss of viability of the pathogen Mycobacterium tuberculosis both in vitroand in a mouse model of infection.
format	article
author	Laure Botella Julien Vaubourgeix Jonathan Livny Dirk Schnappinger
author_facet	Laure Botella Julien Vaubourgeix Jonathan Livny Dirk Schnappinger
author_sort	Laure Botella
title	Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death
title_short	Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death
title_full	Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death
title_fullStr	Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death
title_full_unstemmed	Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death
title_sort	depleting mycobacterium tuberculosis of the transcription termination factor rho causes pervasive transcription and rapid death
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/968cbdf5c5e643a4b7caa914f7812f41
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Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death

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