Structural basis for DNA unwinding at forked dsDNA by two coordinating Pif1 helicases
Pif1 plays multiple roles in maintaining genome stability and preferentially unwinds forked dsDNA. Here the authors solve the structure of Bacteroides sp Pif1 (BaPif1) in complex with a symmetrical double forked dsDNA and provide unprecedented insights into forked dsDNA unwinding by BaPif1.
Saved in:
Main Authors: | Nannan Su, Alicia K. Byrd, Sakshibeedu R. Bharath, Olivia Yang, Yu Jia, Xuhua Tang, Taekjip Ha, Kevin D. Raney, Haiwei Song |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2019
|
Subjects: | |
Online Access: | https://doaj.org/article/96ab66ada22747c98c3f99197371f70c |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Unwinding of a DNA replication fork by a hexameric viral helicase
by: Abid Javed, et al.
Published: (2021) -
The mechanism of DNA unwinding by the eukaryotic replicative helicase
by: Daniel R. Burnham, et al.
Published: (2019) -
Binding fullerenol C60(OH)24 to dsDNA
by: Mariana Pinteala, et al.
Published: (2009) -
DNA unwinding mechanism of a eukaryotic replicative CMG helicase
by: Zuanning Yuan, et al.
Published: (2020) -
Duplex DNA engagement and RPA oppositely regulate the DNA-unwinding rate of CMG helicase
by: Hazal B. Kose, et al.
Published: (2020)