A single-dose live attenuated chimeric vaccine candidate against Zika virus

Abstract The mosquito-borne Zika virus is an emerging pathogen from the Flavivirus genus for which there are no approved antivirals or vaccines. Using the clinically validated PDK-53 dengue virus vaccine strain as a backbone, we created a chimeric dengue/Zika virus, VacDZ, as a live attenuated vacci...

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Autores principales:	Wei-Xin Chin, Regina Ching Hua Lee, Parveen Kaur, Tian Sheng Lew, Thinesshwary Yogarajah, Hao Yuin Kong, Zi-Yun Teo, Cyrill Kafi Salim, Rong-Rong Zhang, Xiao-Feng Li, Sylvie Alonso, Cheng-Feng Qin, Justin Jang Hann Chu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/96aefe18a1c54f6fb1c868ba72e76b1d
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spelling	oai:doaj.org-article:96aefe18a1c54f6fb1c868ba72e76b1d2021-12-02T13:23:50ZA single-dose live attenuated chimeric vaccine candidate against Zika virus10.1038/s41541-021-00282-y2059-0105https://doaj.org/article/96aefe18a1c54f6fb1c868ba72e76b1d2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41541-021-00282-yhttps://doaj.org/toc/2059-0105Abstract The mosquito-borne Zika virus is an emerging pathogen from the Flavivirus genus for which there are no approved antivirals or vaccines. Using the clinically validated PDK-53 dengue virus vaccine strain as a backbone, we created a chimeric dengue/Zika virus, VacDZ, as a live attenuated vaccine candidate against Zika virus. VacDZ demonstrates key markers of attenuation: small plaque phenotype, temperature sensitivity, attenuation of neurovirulence in suckling mice, and attenuation of pathogenicity in interferon deficient adult AG129 mice. VacDZ may be administered as a traditional live virus vaccine, or as a DNA-launched vaccine that produces live VacDZ in vivo after delivery. Both vaccine formulations induce a protective immune response against Zika virus in AG129 mice, which includes neutralising antibodies and a strong Th1 response. This study demonstrates that VacDZ is a safe and effective vaccine candidate against Zika virus.Wei-Xin ChinRegina Ching Hua LeeParveen KaurTian Sheng LewThinesshwary YogarajahHao Yuin KongZi-Yun TeoCyrill Kafi SalimRong-Rong ZhangXiao-Feng LiSylvie AlonsoCheng-Feng QinJustin Jang Hann ChuNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 6, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Wei-Xin Chin Regina Ching Hua Lee Parveen Kaur Tian Sheng Lew Thinesshwary Yogarajah Hao Yuin Kong Zi-Yun Teo Cyrill Kafi Salim Rong-Rong Zhang Xiao-Feng Li Sylvie Alonso Cheng-Feng Qin Justin Jang Hann Chu A single-dose live attenuated chimeric vaccine candidate against Zika virus
description	Abstract The mosquito-borne Zika virus is an emerging pathogen from the Flavivirus genus for which there are no approved antivirals or vaccines. Using the clinically validated PDK-53 dengue virus vaccine strain as a backbone, we created a chimeric dengue/Zika virus, VacDZ, as a live attenuated vaccine candidate against Zika virus. VacDZ demonstrates key markers of attenuation: small plaque phenotype, temperature sensitivity, attenuation of neurovirulence in suckling mice, and attenuation of pathogenicity in interferon deficient adult AG129 mice. VacDZ may be administered as a traditional live virus vaccine, or as a DNA-launched vaccine that produces live VacDZ in vivo after delivery. Both vaccine formulations induce a protective immune response against Zika virus in AG129 mice, which includes neutralising antibodies and a strong Th1 response. This study demonstrates that VacDZ is a safe and effective vaccine candidate against Zika virus.
format	article
author	Wei-Xin Chin Regina Ching Hua Lee Parveen Kaur Tian Sheng Lew Thinesshwary Yogarajah Hao Yuin Kong Zi-Yun Teo Cyrill Kafi Salim Rong-Rong Zhang Xiao-Feng Li Sylvie Alonso Cheng-Feng Qin Justin Jang Hann Chu
author_facet	Wei-Xin Chin Regina Ching Hua Lee Parveen Kaur Tian Sheng Lew Thinesshwary Yogarajah Hao Yuin Kong Zi-Yun Teo Cyrill Kafi Salim Rong-Rong Zhang Xiao-Feng Li Sylvie Alonso Cheng-Feng Qin Justin Jang Hann Chu
author_sort	Wei-Xin Chin
title	A single-dose live attenuated chimeric vaccine candidate against Zika virus
title_short	A single-dose live attenuated chimeric vaccine candidate against Zika virus
title_full	A single-dose live attenuated chimeric vaccine candidate against Zika virus
title_fullStr	A single-dose live attenuated chimeric vaccine candidate against Zika virus
title_full_unstemmed	A single-dose live attenuated chimeric vaccine candidate against Zika virus
title_sort	single-dose live attenuated chimeric vaccine candidate against zika virus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/96aefe18a1c54f6fb1c868ba72e76b1d
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A single-dose live attenuated chimeric vaccine candidate against Zika virus

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