Pyruvate kinase deficiency in sub-Saharan Africa: identification of a highly frequent missense mutation (G829A;Glu277Lys) and association with malaria.

Pyruvate kinase deficiency in sub-Saharan Africa: identification of a highly frequent missense mutation (G829A;Glu277Lys) and association with malaria.

<h4>Background</h4>Pyruvate kinase (PK) deficiency, causing hemolytic anemia, has been associated to malaria protection and its prevalence in sub-Saharan Africa is not known so far. This work shows the results of a study undertaken to determine PK deficiency occurrence in some sub-Sahara...

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Détails bibliographiques
Auteurs principaux: Patrícia Machado, Licínio Manco, Cláudia Gomes, Cristina Mendes, Natércia Fernandes, Graça Salomé, Luis Sitoe, Sérgio Chibute, José Langa, Letícia Ribeiro, Juliana Miranda, Jorge Cano, João Pinto, António Amorim, Virgílio E do Rosário, Ana Paula Arez
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2012
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/96cf8aecbee9430a8a3bb1b7f5201412
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