The tumor suppressor archipelago E3 ligase is required for spermatid differentiation in Drosophila testis

Abstract The human orthologue of the tumor suppressor protein FBW7 is encoded by the Drosophila archipelago (ago) gene. Ago is an F-box protein that gives substrate specificity to its SCF ubiquitin ligase complex. It has a central role in multiple biological processes in a tissue-specific manner suc...

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Autores principales: Viktor Vedelek, Attila L. Kovács, Gábor Juhász, Elham Alzyoud, Rita Sinka
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/96e892ff7bb0435ab8e3ebec8ba2514a
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