Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair

Many cancers develop as a consequence of genomic instability, which induces genomic rearrangements and nucleotide mutations. Failure to correct DNA damage in DNA repair defective cells, such as in <i>BRCA1</i> and <i>BRCA2</i> mutated backgrounds, is directly associated with...

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Autores principales: Ken-ichi Yoshioka, Rika Kusumoto-Matsuo, Yusuke Matsuno, Masamichi Ishiai
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Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/971f15a9eace4865990d774e847291e3
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spelling oai:doaj.org-article:971f15a9eace4865990d774e847291e32021-11-25T17:54:45ZGenomic Instability and Cancer Risk Associated with Erroneous DNA Repair10.3390/ijms2222122541422-00671661-6596https://doaj.org/article/971f15a9eace4865990d774e847291e32021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12254https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Many cancers develop as a consequence of genomic instability, which induces genomic rearrangements and nucleotide mutations. Failure to correct DNA damage in DNA repair defective cells, such as in <i>BRCA1</i> and <i>BRCA2</i> mutated backgrounds, is directly associated with increased cancer risk. Genomic rearrangement is generally a consequence of erroneous repair of DNA double-strand breaks (DSBs), though paradoxically, many cancers develop in the absence of DNA repair defects. DNA repair systems are essential for cell survival, and in cancers deficient in one repair pathway, other pathways can become upregulated. In this review, we examine the current literature on genomic alterations in cancer cells and the association between these alterations and DNA repair pathway inactivation and upregulation.Ken-ichi YoshiokaRika Kusumoto-MatsuoYusuke MatsunoMasamichi IshiaiMDPI AGarticlegenomic instabilitychromosomal instability (CIN)microsatellite instability (MSI)homologous recombination (HR)non-homologous end-joining (NHEJ)microhomology-mediated end-joining (MMEJ)Biology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12254, p 12254 (2021)
institution DOAJ
collection DOAJ
language EN
topic genomic instability
chromosomal instability (CIN)
microsatellite instability (MSI)
homologous recombination (HR)
non-homologous end-joining (NHEJ)
microhomology-mediated end-joining (MMEJ)
Biology (General)
QH301-705.5
Chemistry
QD1-999
spellingShingle genomic instability
chromosomal instability (CIN)
microsatellite instability (MSI)
homologous recombination (HR)
non-homologous end-joining (NHEJ)
microhomology-mediated end-joining (MMEJ)
Biology (General)
QH301-705.5
Chemistry
QD1-999
Ken-ichi Yoshioka
Rika Kusumoto-Matsuo
Yusuke Matsuno
Masamichi Ishiai
Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair
description Many cancers develop as a consequence of genomic instability, which induces genomic rearrangements and nucleotide mutations. Failure to correct DNA damage in DNA repair defective cells, such as in <i>BRCA1</i> and <i>BRCA2</i> mutated backgrounds, is directly associated with increased cancer risk. Genomic rearrangement is generally a consequence of erroneous repair of DNA double-strand breaks (DSBs), though paradoxically, many cancers develop in the absence of DNA repair defects. DNA repair systems are essential for cell survival, and in cancers deficient in one repair pathway, other pathways can become upregulated. In this review, we examine the current literature on genomic alterations in cancer cells and the association between these alterations and DNA repair pathway inactivation and upregulation.
format article
author Ken-ichi Yoshioka
Rika Kusumoto-Matsuo
Yusuke Matsuno
Masamichi Ishiai
author_facet Ken-ichi Yoshioka
Rika Kusumoto-Matsuo
Yusuke Matsuno
Masamichi Ishiai
author_sort Ken-ichi Yoshioka
title Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair
title_short Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair
title_full Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair
title_fullStr Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair
title_full_unstemmed Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair
title_sort genomic instability and cancer risk associated with erroneous dna repair
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/971f15a9eace4865990d774e847291e3
work_keys_str_mv AT kenichiyoshioka genomicinstabilityandcancerriskassociatedwitherroneousdnarepair
AT rikakusumotomatsuo genomicinstabilityandcancerriskassociatedwitherroneousdnarepair
AT yusukematsuno genomicinstabilityandcancerriskassociatedwitherroneousdnarepair
AT masamichiishiai genomicinstabilityandcancerriskassociatedwitherroneousdnarepair
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