Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair
Many cancers develop as a consequence of genomic instability, which induces genomic rearrangements and nucleotide mutations. Failure to correct DNA damage in DNA repair defective cells, such as in <i>BRCA1</i> and <i>BRCA2</i> mutated backgrounds, is directly associated with...
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MDPI AG
2021
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oai:doaj.org-article:971f15a9eace4865990d774e847291e32021-11-25T17:54:45ZGenomic Instability and Cancer Risk Associated with Erroneous DNA Repair10.3390/ijms2222122541422-00671661-6596https://doaj.org/article/971f15a9eace4865990d774e847291e32021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12254https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Many cancers develop as a consequence of genomic instability, which induces genomic rearrangements and nucleotide mutations. Failure to correct DNA damage in DNA repair defective cells, such as in <i>BRCA1</i> and <i>BRCA2</i> mutated backgrounds, is directly associated with increased cancer risk. Genomic rearrangement is generally a consequence of erroneous repair of DNA double-strand breaks (DSBs), though paradoxically, many cancers develop in the absence of DNA repair defects. DNA repair systems are essential for cell survival, and in cancers deficient in one repair pathway, other pathways can become upregulated. In this review, we examine the current literature on genomic alterations in cancer cells and the association between these alterations and DNA repair pathway inactivation and upregulation.Ken-ichi YoshiokaRika Kusumoto-MatsuoYusuke MatsunoMasamichi IshiaiMDPI AGarticlegenomic instabilitychromosomal instability (CIN)microsatellite instability (MSI)homologous recombination (HR)non-homologous end-joining (NHEJ)microhomology-mediated end-joining (MMEJ)Biology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12254, p 12254 (2021) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
genomic instability chromosomal instability (CIN) microsatellite instability (MSI) homologous recombination (HR) non-homologous end-joining (NHEJ) microhomology-mediated end-joining (MMEJ) Biology (General) QH301-705.5 Chemistry QD1-999 |
spellingShingle |
genomic instability chromosomal instability (CIN) microsatellite instability (MSI) homologous recombination (HR) non-homologous end-joining (NHEJ) microhomology-mediated end-joining (MMEJ) Biology (General) QH301-705.5 Chemistry QD1-999 Ken-ichi Yoshioka Rika Kusumoto-Matsuo Yusuke Matsuno Masamichi Ishiai Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair |
description |
Many cancers develop as a consequence of genomic instability, which induces genomic rearrangements and nucleotide mutations. Failure to correct DNA damage in DNA repair defective cells, such as in <i>BRCA1</i> and <i>BRCA2</i> mutated backgrounds, is directly associated with increased cancer risk. Genomic rearrangement is generally a consequence of erroneous repair of DNA double-strand breaks (DSBs), though paradoxically, many cancers develop in the absence of DNA repair defects. DNA repair systems are essential for cell survival, and in cancers deficient in one repair pathway, other pathways can become upregulated. In this review, we examine the current literature on genomic alterations in cancer cells and the association between these alterations and DNA repair pathway inactivation and upregulation. |
format |
article |
author |
Ken-ichi Yoshioka Rika Kusumoto-Matsuo Yusuke Matsuno Masamichi Ishiai |
author_facet |
Ken-ichi Yoshioka Rika Kusumoto-Matsuo Yusuke Matsuno Masamichi Ishiai |
author_sort |
Ken-ichi Yoshioka |
title |
Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair |
title_short |
Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair |
title_full |
Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair |
title_fullStr |
Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair |
title_full_unstemmed |
Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair |
title_sort |
genomic instability and cancer risk associated with erroneous dna repair |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doaj.org/article/971f15a9eace4865990d774e847291e3 |
work_keys_str_mv |
AT kenichiyoshioka genomicinstabilityandcancerriskassociatedwitherroneousdnarepair AT rikakusumotomatsuo genomicinstabilityandcancerriskassociatedwitherroneousdnarepair AT yusukematsuno genomicinstabilityandcancerriskassociatedwitherroneousdnarepair AT masamichiishiai genomicinstabilityandcancerriskassociatedwitherroneousdnarepair |
_version_ |
1718411874645573632 |