Gating of TonB-dependent transporters by substrate-specific forced remodelling

Bacterial outer membrane TonB-dependent transporters (TBDTs) mediate the influx of several nutrients. Here the authors use single-molecule force spectroscopy to show that the interaction between TonB andEscherichia coliTBDT BtuB is mechanically resistant to the pulling that gates the BtuB channel.

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Auteurs principaux: Samuel J. Hickman, Rachael E. M. Cooper, Luca Bellucci, Emanuele Paci, David J. Brockwell
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Accès en ligne:https://doaj.org/article/97330330ecdf49f6a7b535f18d85c41f
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