Gating of TonB-dependent transporters by substrate-specific forced remodelling

Bacterial outer membrane TonB-dependent transporters (TBDTs) mediate the influx of several nutrients. Here the authors use single-molecule force spectroscopy to show that the interaction between TonB andEscherichia coliTBDT BtuB is mechanically resistant to the pulling that gates the BtuB channel.

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Autores principales:	Samuel J. Hickman, Rachael E. M. Cooper, Luca Bellucci, Emanuele Paci, David J. Brockwell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/97330330ecdf49f6a7b535f18d85c41f
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id	oai:doaj.org-article:97330330ecdf49f6a7b535f18d85c41f
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spelling	oai:doaj.org-article:97330330ecdf49f6a7b535f18d85c41f2021-12-02T17:01:17ZGating of TonB-dependent transporters by substrate-specific forced remodelling10.1038/ncomms148042041-1723https://doaj.org/article/97330330ecdf49f6a7b535f18d85c41f2017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14804https://doaj.org/toc/2041-1723Bacterial outer membrane TonB-dependent transporters (TBDTs) mediate the influx of several nutrients. Here the authors use single-molecule force spectroscopy to show that the interaction between TonB andEscherichia coliTBDT BtuB is mechanically resistant to the pulling that gates the BtuB channel.Samuel J. HickmanRachael E. M. CooperLuca BellucciEmanuele PaciDavid J. BrockwellNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Samuel J. Hickman Rachael E. M. Cooper Luca Bellucci Emanuele Paci David J. Brockwell Gating of TonB-dependent transporters by substrate-specific forced remodelling
description	Bacterial outer membrane TonB-dependent transporters (TBDTs) mediate the influx of several nutrients. Here the authors use single-molecule force spectroscopy to show that the interaction between TonB andEscherichia coliTBDT BtuB is mechanically resistant to the pulling that gates the BtuB channel.
format	article
author	Samuel J. Hickman Rachael E. M. Cooper Luca Bellucci Emanuele Paci David J. Brockwell
author_facet	Samuel J. Hickman Rachael E. M. Cooper Luca Bellucci Emanuele Paci David J. Brockwell
author_sort	Samuel J. Hickman
title	Gating of TonB-dependent transporters by substrate-specific forced remodelling
title_short	Gating of TonB-dependent transporters by substrate-specific forced remodelling
title_full	Gating of TonB-dependent transporters by substrate-specific forced remodelling
title_fullStr	Gating of TonB-dependent transporters by substrate-specific forced remodelling
title_full_unstemmed	Gating of TonB-dependent transporters by substrate-specific forced remodelling
title_sort	gating of tonb-dependent transporters by substrate-specific forced remodelling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/97330330ecdf49f6a7b535f18d85c41f
work_keys_str_mv	AT samueljhickman gatingoftonbdependenttransportersbysubstratespecificforcedremodelling AT rachaelemcooper gatingoftonbdependenttransportersbysubstratespecificforcedremodelling AT lucabellucci gatingoftonbdependenttransportersbysubstratespecificforcedremodelling AT emanuelepaci gatingoftonbdependenttransportersbysubstratespecificforcedremodelling AT davidjbrockwell gatingoftonbdependenttransportersbysubstratespecificforcedremodelling
_version_	1718382225632788480

Gating of TonB-dependent transporters by substrate-specific forced remodelling

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