A CSB-PAF1C axis restores processive transcription elongation after DNA damage repair

A CSB-PAF1C axis restores processive transcription elongation after DNA damage repair

The transcription-coupled repair pathway removes transcription-blocking DNA lesions, but how transcription is restored following DNA repair is not clear. Here the authors reveal that the PAF1 complex, while dispensable for the repair process, restores transcription after DNA damage.

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Autores principales: Diana van den Heuvel, Cornelia G. Spruijt, Román González-Prieto, Angela Kragten, Michelle T. Paulsen, Di Zhou, Haoyu Wu, Katja Apelt, Yana van der Weegen, Kevin Yang, Madelon Dijk, Lucia Daxinger, Jurgen A. Marteijn, Alfred C. O. Vertegaal, Mats Ljungman, Michiel Vermeulen, Martijn S. Luijsterburg
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/9746b9cc6bd9439f9dadbc1fe139cf31
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https://doaj.org/article/9746b9cc6bd9439f9dadbc1fe139cf31

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