A CSB-PAF1C axis restores processive transcription elongation after DNA damage repair

The transcription-coupled repair pathway removes transcription-blocking DNA lesions, but how transcription is restored following DNA repair is not clear. Here the authors reveal that the PAF1 complex, while dispensable for the repair process, restores transcription after DNA damage.

Guardado en:

Detalles Bibliográficos
Autores principales:	Diana van den Heuvel, Cornelia G. Spruijt, Román González-Prieto, Angela Kragten, Michelle T. Paulsen, Di Zhou, Haoyu Wu, Katja Apelt, Yana van der Weegen, Kevin Yang, Madelon Dijk, Lucia Daxinger, Jurgen A. Marteijn, Alfred C. O. Vertegaal, Mats Ljungman, Michiel Vermeulen, Martijn S. Luijsterburg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9746b9cc6bd9439f9dadbc1fe139cf31
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9746b9cc6bd9439f9dadbc1fe139cf31
record_format	dspace
spelling	oai:doaj.org-article:9746b9cc6bd9439f9dadbc1fe139cf312021-12-02T15:52:56ZA CSB-PAF1C axis restores processive transcription elongation after DNA damage repair10.1038/s41467-021-21520-w2041-1723https://doaj.org/article/9746b9cc6bd9439f9dadbc1fe139cf312021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21520-whttps://doaj.org/toc/2041-1723The transcription-coupled repair pathway removes transcription-blocking DNA lesions, but how transcription is restored following DNA repair is not clear. Here the authors reveal that the PAF1 complex, while dispensable for the repair process, restores transcription after DNA damage.Diana van den HeuvelCornelia G. SpruijtRomán González-PrietoAngela KragtenMichelle T. PaulsenDi ZhouHaoyu WuKatja ApeltYana van der WeegenKevin YangMadelon DijkLucia DaxingerJurgen A. MarteijnAlfred C. O. VertegaalMats LjungmanMichiel VermeulenMartijn S. LuijsterburgNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Diana van den Heuvel Cornelia G. Spruijt Román González-Prieto Angela Kragten Michelle T. Paulsen Di Zhou Haoyu Wu Katja Apelt Yana van der Weegen Kevin Yang Madelon Dijk Lucia Daxinger Jurgen A. Marteijn Alfred C. O. Vertegaal Mats Ljungman Michiel Vermeulen Martijn S. Luijsterburg A CSB-PAF1C axis restores processive transcription elongation after DNA damage repair
description	The transcription-coupled repair pathway removes transcription-blocking DNA lesions, but how transcription is restored following DNA repair is not clear. Here the authors reveal that the PAF1 complex, while dispensable for the repair process, restores transcription after DNA damage.
format	article
author	Diana van den Heuvel Cornelia G. Spruijt Román González-Prieto Angela Kragten Michelle T. Paulsen Di Zhou Haoyu Wu Katja Apelt Yana van der Weegen Kevin Yang Madelon Dijk Lucia Daxinger Jurgen A. Marteijn Alfred C. O. Vertegaal Mats Ljungman Michiel Vermeulen Martijn S. Luijsterburg
author_facet	Diana van den Heuvel Cornelia G. Spruijt Román González-Prieto Angela Kragten Michelle T. Paulsen Di Zhou Haoyu Wu Katja Apelt Yana van der Weegen Kevin Yang Madelon Dijk Lucia Daxinger Jurgen A. Marteijn Alfred C. O. Vertegaal Mats Ljungman Michiel Vermeulen Martijn S. Luijsterburg
author_sort	Diana van den Heuvel
title	A CSB-PAF1C axis restores processive transcription elongation after DNA damage repair
title_short	A CSB-PAF1C axis restores processive transcription elongation after DNA damage repair
title_full	A CSB-PAF1C axis restores processive transcription elongation after DNA damage repair
title_fullStr	A CSB-PAF1C axis restores processive transcription elongation after DNA damage repair
title_full_unstemmed	A CSB-PAF1C axis restores processive transcription elongation after DNA damage repair
title_sort	csb-paf1c axis restores processive transcription elongation after dna damage repair
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9746b9cc6bd9439f9dadbc1fe139cf31
work_keys_str_mv	AT dianavandenheuvel acsbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT corneliagspruijt acsbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT romangonzalezprieto acsbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT angelakragten acsbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT michelletpaulsen acsbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT dizhou acsbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT haoyuwu acsbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT katjaapelt acsbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT yanavanderweegen acsbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT kevinyang acsbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT madelondijk acsbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT luciadaxinger acsbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT jurgenamarteijn acsbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT alfredcovertegaal acsbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT matsljungman acsbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT michielvermeulen acsbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT martijnsluijsterburg acsbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT dianavandenheuvel csbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT corneliagspruijt csbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT romangonzalezprieto csbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT angelakragten csbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT michelletpaulsen csbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT dizhou csbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT haoyuwu csbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT katjaapelt csbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT yanavanderweegen csbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT kevinyang csbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT madelondijk csbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT luciadaxinger csbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT jurgenamarteijn csbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT alfredcovertegaal csbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT matsljungman csbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT michielvermeulen csbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair AT martijnsluijsterburg csbpaf1caxisrestoresprocessivetranscriptionelongationafterdnadamagerepair
_version_	1718385586545360896

A CSB-PAF1C axis restores processive transcription elongation after DNA damage repair

Ejemplares similares