Hypoxia inducible factor signaling in breast tumors controls spontaneous tumor dissemination in a site-specific manner

Todd et al employ a PyMT-driven spontaneous murine mammary carcinoma model with mammary-specific deletion of hypoxia inducible factors Hif1α, Hif2α, or von Hippel-Lindau factor to further investigate their role in bone and lung metastasis. They find that HIF signaling in breast tumours controls tumo...

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Autores principales:	Vera M. Todd, Lawrence A. Vecchi, Miranda E. Clements, Katherine P. Snow, Cayla D. Ontko, Lauren Himmel, Christopher Pinelli, Marjan Rafat, Rachelle W. Johnson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/975f1c09009840709de77452a7dc73cb
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spelling	oai:doaj.org-article:975f1c09009840709de77452a7dc73cb2021-12-02T15:15:13ZHypoxia inducible factor signaling in breast tumors controls spontaneous tumor dissemination in a site-specific manner10.1038/s42003-021-02648-32399-3642https://doaj.org/article/975f1c09009840709de77452a7dc73cb2021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02648-3https://doaj.org/toc/2399-3642Todd et al employ a PyMT-driven spontaneous murine mammary carcinoma model with mammary-specific deletion of hypoxia inducible factors Hif1α, Hif2α, or von Hippel-Lindau factor to further investigate their role in bone and lung metastasis. They find that HIF signaling in breast tumours controls tumour dissemination in a site-specific manner, which could inform the development of therapies targeting metastasis.Vera M. ToddLawrence A. VecchiMiranda E. ClementsKatherine P. SnowCayla D. OntkoLauren HimmelChristopher PinelliMarjan RafatRachelle W. JohnsonNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Vera M. Todd Lawrence A. Vecchi Miranda E. Clements Katherine P. Snow Cayla D. Ontko Lauren Himmel Christopher Pinelli Marjan Rafat Rachelle W. Johnson Hypoxia inducible factor signaling in breast tumors controls spontaneous tumor dissemination in a site-specific manner
description	Todd et al employ a PyMT-driven spontaneous murine mammary carcinoma model with mammary-specific deletion of hypoxia inducible factors Hif1α, Hif2α, or von Hippel-Lindau factor to further investigate their role in bone and lung metastasis. They find that HIF signaling in breast tumours controls tumour dissemination in a site-specific manner, which could inform the development of therapies targeting metastasis.
format	article
author	Vera M. Todd Lawrence A. Vecchi Miranda E. Clements Katherine P. Snow Cayla D. Ontko Lauren Himmel Christopher Pinelli Marjan Rafat Rachelle W. Johnson
author_facet	Vera M. Todd Lawrence A. Vecchi Miranda E. Clements Katherine P. Snow Cayla D. Ontko Lauren Himmel Christopher Pinelli Marjan Rafat Rachelle W. Johnson
author_sort	Vera M. Todd
title	Hypoxia inducible factor signaling in breast tumors controls spontaneous tumor dissemination in a site-specific manner
title_short	Hypoxia inducible factor signaling in breast tumors controls spontaneous tumor dissemination in a site-specific manner
title_full	Hypoxia inducible factor signaling in breast tumors controls spontaneous tumor dissemination in a site-specific manner
title_fullStr	Hypoxia inducible factor signaling in breast tumors controls spontaneous tumor dissemination in a site-specific manner
title_full_unstemmed	Hypoxia inducible factor signaling in breast tumors controls spontaneous tumor dissemination in a site-specific manner
title_sort	hypoxia inducible factor signaling in breast tumors controls spontaneous tumor dissemination in a site-specific manner
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/975f1c09009840709de77452a7dc73cb
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Hypoxia inducible factor signaling in breast tumors controls spontaneous tumor dissemination in a site-specific manner

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