EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming

T box transcription factor Eomesodermin (EOMES) is induced when naïve T cells are converted to innate memory T cells in response to cytokines. Here the authors show that EOMES is recruited to RUNX3-bound enhancers and interacts with BRG1 during innate memory T cell formation.

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Autores principales:	Nicolas Istaces, Marion Splittgerber, Viviana Lima Silva, Muriel Nguyen, Séverine Thomas, Aurore Le, Younes Achouri, Emilie Calonne, Matthieu Defrance, François Fuks, Stanislas Goriely, Abdulkader Azouz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/977399acbe71487ca1c96fd6df9b2092
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spelling	oai:doaj.org-article:977399acbe71487ca1c96fd6df9b20922021-12-02T16:58:14ZEOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming10.1038/s41467-019-11233-62041-1723https://doaj.org/article/977399acbe71487ca1c96fd6df9b20922019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11233-6https://doaj.org/toc/2041-1723T box transcription factor Eomesodermin (EOMES) is induced when naïve T cells are converted to innate memory T cells in response to cytokines. Here the authors show that EOMES is recruited to RUNX3-bound enhancers and interacts with BRG1 during innate memory T cell formation.Nicolas IstacesMarion SplittgerberViviana Lima SilvaMuriel NguyenSéverine ThomasAurore LeYounes AchouriEmilie CalonneMatthieu DefranceFrançois FuksStanislas GorielyAbdulkader AzouzNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicolas Istaces Marion Splittgerber Viviana Lima Silva Muriel Nguyen Séverine Thomas Aurore Le Younes Achouri Emilie Calonne Matthieu Defrance François Fuks Stanislas Goriely Abdulkader Azouz EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming
description	T box transcription factor Eomesodermin (EOMES) is induced when naïve T cells are converted to innate memory T cells in response to cytokines. Here the authors show that EOMES is recruited to RUNX3-bound enhancers and interacts with BRG1 during innate memory T cell formation.
format	article
author	Nicolas Istaces Marion Splittgerber Viviana Lima Silva Muriel Nguyen Séverine Thomas Aurore Le Younes Achouri Emilie Calonne Matthieu Defrance François Fuks Stanislas Goriely Abdulkader Azouz
author_facet	Nicolas Istaces Marion Splittgerber Viviana Lima Silva Muriel Nguyen Séverine Thomas Aurore Le Younes Achouri Emilie Calonne Matthieu Defrance François Fuks Stanislas Goriely Abdulkader Azouz
author_sort	Nicolas Istaces
title	EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming
title_short	EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming
title_full	EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming
title_fullStr	EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming
title_full_unstemmed	EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming
title_sort	eomes interacts with runx3 and brg1 to promote innate memory cell formation through epigenetic reprogramming
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/977399acbe71487ca1c96fd6df9b2092
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EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming

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