Absence of CD28-CTLA4-PD-L1 Costimulatory Molecules Reduces Herpes Simplex Virus 1 Reactivation
ABSTRACT We previously reported that herpes simplex virus 1 (HSV-1) ICP22 binds to CD80 and suppresses CD80 expression in vitro and in vivo. Similar to ICP22, the cellular costimulatory molecules CD28, CTLA4, and PD-L1 also bind to CD80. In this study, we asked whether, similar to ICP22-null virus,...
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| Main Authors: | , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
American Society for Microbiology
2021
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| Subjects: | |
| Online Access: | https://doaj.org/article/9776df8d282c476986c1363b6893cbc8 |
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