Development of a Flow Cytometry Assay to Predict Immune Checkpoint Blockade-Related Complications

Development of a Flow Cytometry Assay to Predict Immune Checkpoint Blockade-Related Complications

Treatment of advanced melanoma with combined immune checkpoint inhibitor (ICI) therapy is complicated in up to 50% of cases by immune-related adverse events (irAE) that commonly include hepatitis, colitis and skin reactions. We previously reported that pre-therapy expansion of cytomegalovirus (CMV)-...

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Autores principales: Hannah-Lou Schilling, Gunther Glehr, Michael Kapinsky, Norbert Ahrens, Paloma Riquelme, Laura Cordero, Florian Bitterer, Hans J. Schlitt, Edward K. Geissler, Sebastian Haferkamp, James A. Hutchinson, Katharina Kronenberg
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
flow cytometry
assay validation
immune checkpoint inhibition
immune-related adverse events
prediction
effector memory T cells
Immunologic diseases. Allergy
RC581-607
Acceso en línea:https://doaj.org/article/978480e0f0484366a2e24632235b94b1
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https://doaj.org/article/978480e0f0484366a2e24632235b94b1

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