A DNA damage repair gene‐associated signature predicts responses of patients with advanced soft‐tissue sarcoma to treatment with trabectedin

A DNA damage repair gene‐associated signature predicts responses of patients with advanced soft‐tissue sarcoma to treatment with trabectedin

Predictive biomarkers of trabectedin represent an unmet need in advanced soft‐tissue sarcomas (STS). DNA damage repair (DDR) genes, involved in homologous recombination or nucleotide excision repair, had been previously described as biomarkers of trabectedin resistance or sensitivity, respectively....

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Autores principales: David S. Moura, Maria Peña‐Chilet, Juan Antonio Cordero Varela, Ramiro Alvarez‐Alegret, Carolina Agra‐Pujol, Francisco Izquierdo, Rafael Ramos, Luis Ortega‐Medina, Francisco Martin‐Davila, Carolina Castilla‐Ramirez, Carmen Nieves Hernandez‐Leon, Cleofe Romagosa, Maria Angeles Vaz Salgado, Javier Lavernia, Silvia Bagué, Empar Mayodormo‐Aranda, Luis Vicioso, Jose Emilio Hernández Barceló, Jordi Rubio‐Casadevall, Ana deJuan, Maria Concepcion Fiaño‐Valverde, Nadia Hindi, Maria Lopez‐Alvarez, Serena Lacerenza, Joaquin Dopazo, Antonio Gutierrez, Rosa Alvarez, Claudia Valverde, Javier Martinez‐Trufero, Javier Martín‐Broto
Formato: article
Lenguaje:EN
Publicado: Wiley 2021
Materias:
gene signature
predictive biomarkers
trabectedin
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/97947f91b0b04bea97667fd90e9fbdb6
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https://doaj.org/article/97947f91b0b04bea97667fd90e9fbdb6

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