Linear mitochondrial DNA is rapidly degraded by components of the replication machinery

Linear mitochondrial DNA is rapidly degraded by components of the replication machinery

Damaged linearized mtDNA needs to be removed from the cell for mitochondrial genome stability. Here the authors shed light into the identity of the machinery responsible for rapidly degrading linearized DNA, implicating the role of mtDNA replication factors.

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Auteurs principaux: Viktoriya Peeva, Daniel Blei, Genevieve Trombly, Sarah Corsi, Maciej J. Szukszto, Pedro Rebelo-Guiomar, Payam A. Gammage, Alexei P. Kudin, Christian Becker, Janine Altmüller, Michal Minczuk, Gábor Zsurka, Wolfram S. Kunz
Format: article
Langue:EN
Publié: Nature Portfolio 2018
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/979579d067db4608bae2ab8f5bf93bd8
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Internet

https://doaj.org/article/979579d067db4608bae2ab8f5bf93bd8

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