Linear mitochondrial DNA is rapidly degraded by components of the replication machinery

Linear mitochondrial DNA is rapidly degraded by components of the replication machinery

Damaged linearized mtDNA needs to be removed from the cell for mitochondrial genome stability. Here the authors shed light into the identity of the machinery responsible for rapidly degrading linearized DNA, implicating the role of mtDNA replication factors.

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Detalles Bibliográficos
Autores principales: Viktoriya Peeva, Daniel Blei, Genevieve Trombly, Sarah Corsi, Maciej J. Szukszto, Pedro Rebelo-Guiomar, Payam A. Gammage, Alexei P. Kudin, Christian Becker, Janine Altmüller, Michal Minczuk, Gábor Zsurka, Wolfram S. Kunz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/979579d067db4608bae2ab8f5bf93bd8
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https://doaj.org/article/979579d067db4608bae2ab8f5bf93bd8

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