Linear mitochondrial DNA is rapidly degraded by components of the replication machinery

Damaged linearized mtDNA needs to be removed from the cell for mitochondrial genome stability. Here the authors shed light into the identity of the machinery responsible for rapidly degrading linearized DNA, implicating the role of mtDNA replication factors.

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Autores principales:	Viktoriya Peeva, Daniel Blei, Genevieve Trombly, Sarah Corsi, Maciej J. Szukszto, Pedro Rebelo-Guiomar, Payam A. Gammage, Alexei P. Kudin, Christian Becker, Janine Altmüller, Michal Minczuk, Gábor Zsurka, Wolfram S. Kunz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/979579d067db4608bae2ab8f5bf93bd8
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spelling	oai:doaj.org-article:979579d067db4608bae2ab8f5bf93bd82021-12-02T14:39:06ZLinear mitochondrial DNA is rapidly degraded by components of the replication machinery10.1038/s41467-018-04131-w2041-1723https://doaj.org/article/979579d067db4608bae2ab8f5bf93bd82018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04131-whttps://doaj.org/toc/2041-1723Damaged linearized mtDNA needs to be removed from the cell for mitochondrial genome stability. Here the authors shed light into the identity of the machinery responsible for rapidly degrading linearized DNA, implicating the role of mtDNA replication factors.Viktoriya PeevaDaniel BleiGenevieve TromblySarah CorsiMaciej J. SzuksztoPedro Rebelo-GuiomarPayam A. GammageAlexei P. KudinChristian BeckerJanine AltmüllerMichal MinczukGábor ZsurkaWolfram S. KunzNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Viktoriya Peeva Daniel Blei Genevieve Trombly Sarah Corsi Maciej J. Szukszto Pedro Rebelo-Guiomar Payam A. Gammage Alexei P. Kudin Christian Becker Janine Altmüller Michal Minczuk Gábor Zsurka Wolfram S. Kunz Linear mitochondrial DNA is rapidly degraded by components of the replication machinery
description	Damaged linearized mtDNA needs to be removed from the cell for mitochondrial genome stability. Here the authors shed light into the identity of the machinery responsible for rapidly degrading linearized DNA, implicating the role of mtDNA replication factors.
format	article
author	Viktoriya Peeva Daniel Blei Genevieve Trombly Sarah Corsi Maciej J. Szukszto Pedro Rebelo-Guiomar Payam A. Gammage Alexei P. Kudin Christian Becker Janine Altmüller Michal Minczuk Gábor Zsurka Wolfram S. Kunz
author_facet	Viktoriya Peeva Daniel Blei Genevieve Trombly Sarah Corsi Maciej J. Szukszto Pedro Rebelo-Guiomar Payam A. Gammage Alexei P. Kudin Christian Becker Janine Altmüller Michal Minczuk Gábor Zsurka Wolfram S. Kunz
author_sort	Viktoriya Peeva
title	Linear mitochondrial DNA is rapidly degraded by components of the replication machinery
title_short	Linear mitochondrial DNA is rapidly degraded by components of the replication machinery
title_full	Linear mitochondrial DNA is rapidly degraded by components of the replication machinery
title_fullStr	Linear mitochondrial DNA is rapidly degraded by components of the replication machinery
title_full_unstemmed	Linear mitochondrial DNA is rapidly degraded by components of the replication machinery
title_sort	linear mitochondrial dna is rapidly degraded by components of the replication machinery
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/979579d067db4608bae2ab8f5bf93bd8
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Linear mitochondrial DNA is rapidly degraded by components of the replication machinery

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