Investigation of cationicity and structure of pseudin-2 analogues for enhanced bacterial selectivity and anti-inflammatory activity

Abstract Pseudin-2 (Ps), isolated from the frog Pseudis paradoxa, exhibits potent antibacterial activity and cytotoxicity. To develop antimicrobial peptides with anti-inflammatory activity and low cytotoxicity, we designed Ps analogues with Lys substitutions, resulting in elevated amphipathic α-heli...

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Autores principales: Dasom Jeon, Min-Cheol Jeong, Binu Jacob, Jeong Kyu Bang, Eun-Hee Kim, Chaejoon Cheong, In Duk Jung, Yoonkyung Park, Yangmee Kim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/97a022e25a9a4df2932b8be12cb23e86
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