A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants

A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants

Here the authors report the isolation and structural and biological characterization of a humanized angiotensin-converting enzyme 2 (ACE2)-blocking antibody, which exterts potent inhibitory activity against SARS-CoV and circulating global SARS-CoV-2 lineages both in vitro and in hACE2 mouse model.

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Auteurs principaux: Yanyun Du, Rui Shi, Ying Zhang, Xiaomin Duan, Li Li, Jing Zhang, Fengze Wang, Ruixue Zhang, Hao Shen, Yue Wang, Zheng Wu, Qianwen Peng, Ting Pan, Wanwei Sun, Weijin Huang, Yue Feng, Hui Feng, Junyu Xiao, Wenjie Tan, Youchun Wang, Chenhui Wang, Jinghua Yan
Format: article
Langue:EN
Publié: Nature Portfolio 2021
Sujets:
Science
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Accès en ligne:https://doaj.org/article/97a9b5fb5db54f02ba7db4036da85f1f
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Résumé:Here the authors report the isolation and structural and biological characterization of a humanized angiotensin-converting enzyme 2 (ACE2)-blocking antibody, which exterts potent inhibitory activity against SARS-CoV and circulating global SARS-CoV-2 lineages both in vitro and in hACE2 mouse model.

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