Three-Component Synthesis of 2-Amino-3-cyano-4<i>H</i>-chromenes, In Silico Analysis of Their Pharmacological Profile, and In Vitro Anticancer and Antifungal Testing

Three-Component Synthesis of 2-Amino-3-cyano-4<i>H</i>-chromenes, In Silico Analysis of Their Pharmacological Profile, and In Vitro Anticancer and Antifungal Testing

Chromenes are compounds that may be useful for inhibiting topoisomerase and cytochrome, enzymes involved in the growth of cancer and fungal cells, respectively. The aim of this study was to synthesize a series of some novel 2-amino-3-cyano-4-aryl-6,7-methylendioxy-4<i>H</i>-chromenes <...

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Main Authors: Alberto Feliciano, Omar Gómez-García, Carlos H. Escalante, Mario A. Rodríguez-Hernández, Mariana Vargas-Fuentes, Dulce Andrade-Pavón, Lourdes Villa-Tanaca, Cecilio Álvarez-Toledano, María Teresa Ramírez-Apan, Miguel A. Vázquez, Joaquín Tamariz, Francisco Delgado
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
2-amino-3-cyano-4<i>H</i>-chromenes
cytotoxicity
topoisomerase I
antifungal activity
CYP51
<i>Candida</i> spp.
Medicine
R
Pharmacy and materia medica
RS1-441
Online Access:https://doaj.org/article/97b971ae3c79401fb4955520971950c1
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https://doaj.org/article/97b971ae3c79401fb4955520971950c1

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