Three-Component Synthesis of 2-Amino-3-cyano-4<i>H</i>-chromenes, In Silico Analysis of Their Pharmacological Profile, and In Vitro Anticancer and Antifungal Testing

Three-Component Synthesis of 2-Amino-3-cyano-4<i>H</i>-chromenes, In Silico Analysis of Their Pharmacological Profile, and In Vitro Anticancer and Antifungal Testing

Chromenes are compounds that may be useful for inhibiting topoisomerase and cytochrome, enzymes involved in the growth of cancer and fungal cells, respectively. The aim of this study was to synthesize a series of some novel 2-amino-3-cyano-4-aryl-6,7-methylendioxy-4<i>H</i>-chromenes <...

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Détails bibliographiques
Auteurs principaux: Alberto Feliciano, Omar Gómez-García, Carlos H. Escalante, Mario A. Rodríguez-Hernández, Mariana Vargas-Fuentes, Dulce Andrade-Pavón, Lourdes Villa-Tanaca, Cecilio Álvarez-Toledano, María Teresa Ramírez-Apan, Miguel A. Vázquez, Joaquín Tamariz, Francisco Delgado
Format: article
Langue:EN
Publié: MDPI AG 2021
Sujets:
2-amino-3-cyano-4<i>H</i>-chromenes
cytotoxicity
topoisomerase I
antifungal activity
CYP51
<i>Candida</i> spp.
Medicine
R
Pharmacy and materia medica
RS1-441
Accès en ligne:https://doaj.org/article/97b971ae3c79401fb4955520971950c1
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https://doaj.org/article/97b971ae3c79401fb4955520971950c1

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