A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport

Neurotransmitter:sodium symporters (NSS) modulate the duration and magnitude of signaling via the sodium-coupled reuptake of neurotransmitters. Here the authors describe quantitative single molecule imaging of ligand-induced, functional dynamics of both intracellular and extracellular surfaces of Le...

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Autores principales:	Daniel S. Terry, Rachel A. Kolster, Matthias Quick, Michael V. LeVine, George Khelashvili, Zhou Zhou, Harel Weinstein, Jonathan A. Javitch, Scott C. Blanchard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/97de270984c541fa90101d0a86508a1f
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spelling	oai:doaj.org-article:97de270984c541fa90101d0a86508a1f2021-12-02T17:31:27ZA partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport10.1038/s41467-017-02202-y2041-1723https://doaj.org/article/97de270984c541fa90101d0a86508a1f2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02202-yhttps://doaj.org/toc/2041-1723Neurotransmitter:sodium symporters (NSS) modulate the duration and magnitude of signaling via the sodium-coupled reuptake of neurotransmitters. Here the authors describe quantitative single molecule imaging of ligand-induced, functional dynamics of both intracellular and extracellular surfaces of LeuT, further defining the mechanism for NSS transport.Daniel S. TerryRachel A. KolsterMatthias QuickMichael V. LeVineGeorge KhelashviliZhou ZhouHarel WeinsteinJonathan A. JavitchScott C. BlanchardNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel S. Terry Rachel A. Kolster Matthias Quick Michael V. LeVine George Khelashvili Zhou Zhou Harel Weinstein Jonathan A. Javitch Scott C. Blanchard A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport
description	Neurotransmitter:sodium symporters (NSS) modulate the duration and magnitude of signaling via the sodium-coupled reuptake of neurotransmitters. Here the authors describe quantitative single molecule imaging of ligand-induced, functional dynamics of both intracellular and extracellular surfaces of LeuT, further defining the mechanism for NSS transport.
format	article
author	Daniel S. Terry Rachel A. Kolster Matthias Quick Michael V. LeVine George Khelashvili Zhou Zhou Harel Weinstein Jonathan A. Javitch Scott C. Blanchard
author_facet	Daniel S. Terry Rachel A. Kolster Matthias Quick Michael V. LeVine George Khelashvili Zhou Zhou Harel Weinstein Jonathan A. Javitch Scott C. Blanchard
author_sort	Daniel S. Terry
title	A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport
title_short	A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport
title_full	A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport
title_fullStr	A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport
title_full_unstemmed	A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport
title_sort	partially-open inward-facing intermediate conformation of leut is associated with na+ release and substrate transport
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/97de270984c541fa90101d0a86508a1f
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A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport

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